CRH and lysine-vasopressin stimuation tests in the diagnosis of hypoadrenalism secondary to hypothalamic or pituitary disorders

L. Cantalamessa, A. Catania, M. Baldini, A. Orsatti, P. Motta, G. Peracchi

Research output: Contribution to journalArticlepeer-review

Abstract

Ten patients with secondary hypoadrenalism have been tested with corticotropin releasing hormone (CRH) and lysine-vasopressin (LVP). One patient had isolated ACTH deficiency; 9 had deficiency of other pituitary hormones attributable to a primary pituitary disease in 3 and to an hypthalamic disorder in 6. After CRH administration, a definite increase in plasma ACTH was observed in all 6 patients with pituitary disease and in the patient with isolated ACTH deficiency. In the responsive patients, ACTH showed a delayed and prolonged pattern of response. Lysine-vasopressin administration produced an increase in plasma ACTH in 4 of the 6 hypothalamic patients and no response in those with pituitary disease and in the patient with isolated ACTH deficiency. These findings suggest that CRH represents a reliable test in differentiating hypothalamic from pituitary adrenal failure; LVP appeared a less sensitive diagnostic test.

Original languageEnglish
Pages (from-to)389-393
Number of pages5
JournalHormone and Metabolic Research
Volume22
Issue number7
Publication statusPublished - 1990

Keywords

  • CRH
  • hypopituitarism
  • hypothalamic disorders
  • LVP
  • pituitary disorders
  • secondary hypoadrenalism

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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