Ten patients with secondary hypoadrenalism have been tested with corticotropin releasing hormone (CRH) and lysine-vasopressin (LVP). One patient had isolated ACTH deficiency; 9 had deficiency of other pituitary hormones attributable to a primary pituitary disease in 3 and to an hypthalamic disorder in 6. After CRH administration, a definite increase in plasma ACTH was observed in all 6 patients with pituitary disease and in the patient with isolated ACTH deficiency. In the responsive patients, ACTH showed a delayed and prolonged pattern of response. Lysine-vasopressin administration produced an increase in plasma ACTH in 4 of the 6 hypothalamic patients and no response in those with pituitary disease and in the patient with isolated ACTH deficiency. These findings suggest that CRH represents a reliable test in differentiating hypothalamic from pituitary adrenal failure; LVP appeared a less sensitive diagnostic test.
|Number of pages||5|
|Journal||Hormone and Metabolic Research|
|Publication status||Published - 1990|
- hypothalamic disorders
- pituitary disorders
- secondary hypoadrenalism
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