We developed and evaluated objective manometric criteria that define transient lower esophageal sphincter (LES) relaxation. In 23 normal subjects and 9 patients with gastroesophageal reflux disease, systematic analysis of swallow-induced LES relaxation showed that dry swallows preceded LES relaxation by a median of 1.4 s. The relaxation rate was always >1 mmHg/s, the relaxation nadir always occurred within 7 s, and the duration of relaxation was 1 mmHg/s. Sixteen pressure falls were classified as a gradual downward drift in LES pressure, which in 15 cases was 10 s can also be classified as transient LES relaxations irrespective of the timing of LES relaxation to swallowing.
|Journal||American Journal of Physiology - Gastrointestinal and Liver Physiology|
|Issue number||1 31-1|
|Publication status||Published - 1995|
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)