Criteria for objective definition of transient lower esophageal sphincter relaxation

R. H. Holloway, R. Penagini, A. C. Ireland

Research output: Contribution to journalArticlepeer-review


We developed and evaluated objective manometric criteria that define transient lower esophageal sphincter (LES) relaxation. In 23 normal subjects and 9 patients with gastroesophageal reflux disease, systematic analysis of swallow-induced LES relaxation showed that dry swallows preceded LES relaxation by a median of 1.4 s. The relaxation rate was always >1 mmHg/s, the relaxation nadir always occurred within 7 s, and the duration of relaxation was 1 mmHg/s. Sixteen pressure falls were classified as a gradual downward drift in LES pressure, which in 15 cases was 10 s can also be classified as transient LES relaxations irrespective of the timing of LES relaxation to swallowing.

Original languageEnglish
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Issue number1 31-1
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology
  • Agricultural and Biological Sciences(all)


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