Criteria for objective definition of transient lower esophageal sphincter relaxation

R. H. Holloway, R. Penagini, A. C. Ireland

Research output: Contribution to journalArticle

271 Citations (Scopus)

Abstract

We developed and evaluated objective manometric criteria that define transient lower esophageal sphincter (LES) relaxation. In 23 normal subjects and 9 patients with gastroesophageal reflux disease, systematic analysis of swallow-induced LES relaxation showed that dry swallows preceded LES relaxation by a median of 1.4 s. The relaxation rate was always >1 mmHg/s, the relaxation nadir always occurred within 7 s, and the duration of relaxation was 1 mmHg/s. Sixteen pressure falls were classified as a gradual downward drift in LES pressure, which in 15 cases was 10 s can also be classified as transient LES relaxations irrespective of the timing of LES relaxation to swallowing.

Original languageEnglish
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume268
Issue number1 31-1
Publication statusPublished - 1995

Fingerprint

esophageal sphincter
Lower Esophageal Sphincter
Swallows
Deglutition
gastroesophageal reflux
Pressure
Gastroesophageal Reflux
duration

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology
  • Agricultural and Biological Sciences(all)

Cite this

Criteria for objective definition of transient lower esophageal sphincter relaxation. / Holloway, R. H.; Penagini, R.; Ireland, A. C.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 268, No. 1 31-1, 1995.

Research output: Contribution to journalArticle

@article{d9267278441944e0abb39d30d700ae19,
title = "Criteria for objective definition of transient lower esophageal sphincter relaxation",
abstract = "We developed and evaluated objective manometric criteria that define transient lower esophageal sphincter (LES) relaxation. In 23 normal subjects and 9 patients with gastroesophageal reflux disease, systematic analysis of swallow-induced LES relaxation showed that dry swallows preceded LES relaxation by a median of 1.4 s. The relaxation rate was always >1 mmHg/s, the relaxation nadir always occurred within 7 s, and the duration of relaxation was 1 mmHg/s. Sixteen pressure falls were classified as a gradual downward drift in LES pressure, which in 15 cases was 10 s can also be classified as transient LES relaxations irrespective of the timing of LES relaxation to swallowing.",
author = "Holloway, {R. H.} and R. Penagini and Ireland, {A. C.}",
year = "1995",
language = "English",
volume = "268",
journal = "American Journal of Physiology",
issn = "0363-6119",
publisher = "American Physiological Society",
number = "1 31-1",

}

TY - JOUR

T1 - Criteria for objective definition of transient lower esophageal sphincter relaxation

AU - Holloway, R. H.

AU - Penagini, R.

AU - Ireland, A. C.

PY - 1995

Y1 - 1995

N2 - We developed and evaluated objective manometric criteria that define transient lower esophageal sphincter (LES) relaxation. In 23 normal subjects and 9 patients with gastroesophageal reflux disease, systematic analysis of swallow-induced LES relaxation showed that dry swallows preceded LES relaxation by a median of 1.4 s. The relaxation rate was always >1 mmHg/s, the relaxation nadir always occurred within 7 s, and the duration of relaxation was 1 mmHg/s. Sixteen pressure falls were classified as a gradual downward drift in LES pressure, which in 15 cases was 10 s can also be classified as transient LES relaxations irrespective of the timing of LES relaxation to swallowing.

AB - We developed and evaluated objective manometric criteria that define transient lower esophageal sphincter (LES) relaxation. In 23 normal subjects and 9 patients with gastroesophageal reflux disease, systematic analysis of swallow-induced LES relaxation showed that dry swallows preceded LES relaxation by a median of 1.4 s. The relaxation rate was always >1 mmHg/s, the relaxation nadir always occurred within 7 s, and the duration of relaxation was 1 mmHg/s. Sixteen pressure falls were classified as a gradual downward drift in LES pressure, which in 15 cases was 10 s can also be classified as transient LES relaxations irrespective of the timing of LES relaxation to swallowing.

UR - http://www.scopus.com/inward/record.url?scp=0028891589&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028891589&partnerID=8YFLogxK

M3 - Article

VL - 268

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0363-6119

IS - 1 31-1

ER -