Criteria, frequency, and duration of clinical remission in psoriatic arthritis patients with peripheral involvement requiring second-line drugs

Fabrizio Cantini, Laura Niccoli, Carlotta Nannini, Emanuele Cassarà, Paolo Pasquetti, Ignazio Olivieri, Carlo Salvarani

Research output: Contribution to journalArticlepeer-review

Abstract

This article outlines our case-control, prospective, 6-year followup study to evaluate the frequency of clinical remission and duration of remission episodes in patients with peripheral psoriatic arthritis (PsA). All case patients were consecutive new outpatients with peripheral PsA requiring second-line drugs. Controls were consecutive new outpatients with rheumatoid arthritis (RA). Modified American College of Rheumatology criteria for RA were used to assess the remission in patients with PsA. One or more episodes of remission occurred in 57/236 (24.1%) PsA patients and in 20/268 (7.5%) controls (p <0.001). No significant difference was recorded for duration of remissions between the group receiving traditional disease modifying antirheumatic drug (DMARD) and the anti-tumor necrosis factor (TNF) group: 11 ± 7.2 and 13.3 ± 8.1 months, respectively (p = NS). The duration of remission after interruption of therapy was 12 ± 2.4 months for the PsA group and 3 ± 1.5 months for patients with RA (p <0.001). No predictor of remission at diagnosis could be determined by multivariate analysis. Based on our findings, remission is possible in up to 24% of patients with peripheral PsA. It is significantly more frequent, but not longer, in patients receiving anti-TNF drugs compared to those treated with traditional DMARD.

Original languageEnglish
Pages (from-to)78-80
Number of pages3
JournalJournal of Rheumatology
Volume36
Issue numberSUPPL. 83
DOIs
Publication statusPublished - Aug 2009

Keywords

  • Anti-tumor necrosis factor
  • Disease activity
  • Disease modifying antirheumatic drugs
  • Psoriatic arthritis
  • Remission
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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