Critical analysis of transcriptional and post-transcriptional regulatory networks in multiple myeloma

Marta Biasiolo, Mattia Forcato, Lino Possamai, Francesco Ferrari, Luca Agnelli, Marta Lionetti, Katia Todoerti, Antonino Neri, Massimo Marchiori, Stefania Bortoluzzi, Silvio Bicciato

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Network analysis has emerged as a powerful approach to understand complex phenomena and organization in social, technological and biological systems. In particular, it is increasingly recognized the role played by the topology of cellular networks, the intricate web of interactions among genes, proteins and other molecules regulating cell activity, in unveiling the biological mechanisms underlying the physiological states of living organisms. In this study, critical analysis of network components has been applied to inspect the transcriptional and post-transcriptional regulatory networks reconstructed from mRNA and microRNA expression data of multiple myeloma (MM) samples. Specifically, the importance of a gene as a putative regulatory element has been assessed calculating the drop in the network performance caused by its deactivation instead of quantifying its degree of connectivity. The application of critical analysis to transcriptional and post-transcriptional regulatory networks allowed inferring novel regulatory relations potentially functional in multiple myeloma.

Original languageEnglish
Title of host publicationPacific Symposium on Biocomputing 2010, PSB 2010
Pages397-408
Number of pages12
Publication statusPublished - 2010
Event15th Pacific Symposium on Biocomputing, PSB 2010 - Kamuela, HI, United States
Duration: Jan 4 2010Jan 8 2010

Other

Other15th Pacific Symposium on Biocomputing, PSB 2010
CountryUnited States
CityKamuela, HI
Period1/4/101/8/10

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ASJC Scopus subject areas

  • Computational Theory and Mathematics
  • Biomedical Engineering
  • Medicine(all)

Cite this

Biasiolo, M., Forcato, M., Possamai, L., Ferrari, F., Agnelli, L., Lionetti, M., Todoerti, K., Neri, A., Marchiori, M., Bortoluzzi, S., & Bicciato, S. (2010). Critical analysis of transcriptional and post-transcriptional regulatory networks in multiple myeloma. In Pacific Symposium on Biocomputing 2010, PSB 2010 (pp. 397-408)