Critical assessment of tools to predict clinically insignificant prostate cancer at radical prostatectomy in contemporary men

Felix K H Chun, Alexander Haese, Sascha A. Ahyai, Jochen Walz, Nazareno Suardi, Umberto Capitanio, Markus Graefen, Andreas Erbersdobler, Hartwig Huland, Pierre I. Karakiewicz

Research output: Contribution to journalArticle

Abstract

BACKGROUND. Overtreatment of prostate cancer (PCa) is a concern, especially in patients who might qualify for the diagnosis of insignificant prostate cancer (IPCa). The ability to identify IPCa prior to definitive therapy was tested. METHODS. In a cohort of 1132 men a nomogram was developed to predict the probability of IPCa. Predictors consisted of prostate-specific antigen (PSA), clinical stage, biopsy Gleason sum, core cancer length and percentage of positive biopsy cores (percent positive cores). IPCa was defined as organ-confined PCa (OC) with tumor volume (TV)

Original languageEnglish
Pages (from-to)701-709
Number of pages9
JournalCancer
Volume113
Issue number4
DOIs
Publication statusPublished - Aug 15 2008

Keywords

  • Clinically insignificant prostate cancer
  • Clinically meaningful prostate cancer
  • Nomogram
  • Tumor volume

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Chun, F. K. H., Haese, A., Ahyai, S. A., Walz, J., Suardi, N., Capitanio, U., Graefen, M., Erbersdobler, A., Huland, H., & Karakiewicz, P. I. (2008). Critical assessment of tools to predict clinically insignificant prostate cancer at radical prostatectomy in contemporary men. Cancer, 113(4), 701-709. https://doi.org/10.1002/cncr.23610