Critical choices for modeling breast cancer in transgenic mouse models

Isabella Caligiuri; Flavio Rizzolio; Silvia Boffo; Antonio Giordano; Giuseppe Toffoli

doi:10.1002/jcp.24031

Critical choices for modeling breast cancer in transgenic mouse models

Isabella Caligiuri, Flavio Rizzolio, Silvia Boffo, Antonio Giordano, Giuseppe Toffoli

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

Modeling breast cancer in the mouse has helped to better define the heterogeneity of human breast cancer. In the recent past, it has become evident that some limitations have restricted the potential benefits that can be achieved with this approach. In this review, we highlight some key points that should be taken into account when the mouse is used, with special emphasis on transgenic models.

Original language	English
Pages (from-to)	2988-2991
Number of pages	4
Journal	Journal of Cellular Physiology
Volume	227
Issue number	8
DOIs	https://doi.org/10.1002/jcp.24031
Publication status	Published - Aug 2012

ASJC Scopus subject areas

Clinical Biochemistry
Cell Biology
Physiology

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10.1002/jcp.24031

Cite this

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abstract = "Modeling breast cancer in the mouse has helped to better define the heterogeneity of human breast cancer. In the recent past, it has become evident that some limitations have restricted the potential benefits that can be achieved with this approach. In this review, we highlight some key points that should be taken into account when the mouse is used, with special emphasis on transgenic models.",

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AU - Giordano, Antonio

AU - Toffoli, Giuseppe

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Critical choices for modeling breast cancer in transgenic mouse models

Abstract

ASJC Scopus subject areas

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