Critical concepts, practice recommendations, and research perspectives of pixantrone therapy in non-Hodgkin lymphoma: A SIE, SIES, and GITMO consensus paper

Pierluigi Zinzani, Paolo Corradini, Maurizio Martelli, Giorgio Minotti, Stefano Oliva, Michele Spina, Giovanni Barosi, Sante Tura

Research output: Contribution to journalArticle

Abstract

Objectives: In this paper, we present a review of critical concepts and research perspectives and produce recommendations on the optimal use of pixantrone in non-Hodgkin lymphoma (NHL) by group discussion from an expert panel appointed by the Italian Society of Hematology and the affiliate societies, Società Italiana di Ematologia Sperimentale and Gruppo Italiano Trapianto di Midollo Osseo. Methods: Recommendations were produced using the Delphi process. Scientific evidence on pixantrone efficacy was analyzed using Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) methodology in the areas where at least one randomized trial was published. The following key issues were addressed for practical recommendations: pixantrone monotherapy in aggressive relapsed or refractory non-Hodgkin B-cell lymphomas and toxicity risk management in patients candidates to pixantrone. Results and conclusions: After a balanced and value-oriented discussion, the panel agreed that the benefit/risk profile was in favor of pixantrone in the treatment of adult patients with multiply relapsed or refractory aggressive NHL B-cell lymphomas. Pixantrone was deemed to be contraindicated in patients with uncontrolled cardiovascular disease. Despite a low rate of cardiotoxicity of pixantrone reported in clinical trials, the panel recommended that all patients receiving pixantrone should undergo periodical cardiac monitoring.

Original languageEnglish
JournalEuropean Journal of Haematology
DOIs
Publication statusAccepted/In press - 2016

Keywords

  • GRADE methodology
  • Guidelines
  • Non-Hodgkin lymphoma
  • Pixantrone

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Critical concepts, practice recommendations, and research perspectives of pixantrone therapy in non-Hodgkin lymphoma: A SIE, SIES, and GITMO consensus paper'. Together they form a unique fingerprint.

Cite this