Critical evaluation of the variants influencing the clinical response of vitiligo: Study of 60 cases treated with ultraviolet B narrow-band phototherapy

V. Brazzelli, M. Antoninetti, S. Palazzini, T. Barbagallo, A. de Silvestri, G. Borroni

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The treatment of vitiligo is still a challenge, but ultraviolet B narrow-band (UVB-NB) therapy has been recently reported to be an effective and safe therapeutic option in patients with vitiligo. Objective: The purpose of this study is a critical evaluation of the variants (body sites, age, duration of the disease, and duration of the therapy) influencing the clinical response to UVB-NB therapy. Methods: Sixty patients (23 male and 37 female), aged 6 to 70 years, with vitiligo, were treated with UVB-NB therapy over a maximum period of 2 years. The evaluation of the percentage of repigmentation was done through photographs. Results: The lesions located on the face obtained a complete repigmentation in 68% of the patients, on the neck in 57.89%, and on the trunk in 50% within the first year of the therapy. In young patients vs. adults patients, the lesions located on the neck obtained a complete repigmentation in 83.33% vs. 46.15%, on the upper limbs in 28.57% vs. 9.52%, and on the lower limbs in 25% vs. 16.67%. In patients with vitiligo of recent onset, the lesions located on the neck obtained a complete repigmentation in 83.33%, on the upper limbs in 33.33%, and on the lower limbs in 28.57%. Hands did not give a positive response in either groups. Conclusion: This study shows that certain body sites respond better than others to the UVB-NB therapy; patients, aged less than 20 years, with recent vitiligo, achieve more repigmentation; the duration of the therapy can influence the response of the lesions over hands and lower limbs, showing only mild repigmentation.

Original languageEnglish
Pages (from-to)1369-1374
Number of pages6
JournalJournal of the European Academy of Dermatology and Venereology
Volume21
Issue number10
DOIs
Publication statusPublished - Nov 2007

Keywords

  • Body sites
  • Clinical response
  • UVB-NB phototherapy
  • Vitiligo

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

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