Miopatia e neuropatia del paziente critico (CRIMYNE) in un rigetto di trapianto polmonare Caso clinico

Translated title of the contribution: Critical Illness Myopathy and Neuropathy (CRIMYNE) in a rejected transplanted lung a case report

Chiara Becchi, Antonello Grippo, Mohamed Al Malyan

Research output: Contribution to journalArticle


Early or delayed neuromuscular complications may develop in 30-60% of transplanted critically ill patients (pts). Both Critical Illness Polyneuropathy(CIP) and myopathy (CIM) are commonly present in critically ill pts, and are rarely described in transplanted pts. Polyneuropathy usually manifests variably and is frequently associated with less defined myopathy. These two pathologies are recently considered as a single complex defined as "Critical illness myopathy & neuropathy"(CRIMYNE). The precise etiopathogenesis of this complex is not fully understood. However many factors are incriminated. Systemic Inflammatory Response Syndrome (SIRS) is considered highly responsible as a close relationship between SIRS and polyneuropathy has been established. In the literature, evidences are available, though not underlined, that sepsis-free transplanted patients have developed CRIMYNE. Identification of CRIMYNE assumes prognostic significance as its recovery is faster than a pure axonopathy. Despite the existence of reports describing the presence of mixed forms, the terms CIP and CIM are still used independently to express the same clinical form. It is used also to describe muscular involvement within CIP syndrome. To describe the late occurance of CRIMYNE in an organ transplant in absence of sepsis, and to evidence its prognostic value, we report a pt with rejected lung transplant who has developed abrupt onset muscle weakness at 40 months from transplantation.

Original languageItalian
Pages (from-to)267-280
Number of pages14
JournalActa Anaesthesiologica Italica / Anaesthesia and Intensive Care in Italy
Issue number3
Publication statusPublished - 2004


ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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