Critical role of HMGA proteins in cancer cell chemoresistance

Daniela D’Angelo, Paula Mussnich, Claudio Arra, Sabrina Battista, Alfredo Fusco

Research output: Contribution to journalReview article

Abstract

The high-mobility group A (HMGA) proteins are frequently overexpressed in human malignancies and correlate with the presence of metastases and reduced patient survival. Here, we highlight the main studies evidencing a critical role of HMGA in chemoresistance, mainly by activating Akt signaling, impairing p53 activity, and regulating the expression of microRNAs that target genes involved in the susceptibility of cancer cells to antineoplastic agents. Therefore, these studies account for the association of HMGA overexpression with patient poor outcome, indicating the impairment of HMGA as a fascinating perspective for effectively improving cancer therapy.

Original languageEnglish
Pages (from-to)353-360
Number of pages8
JournalJournal of Molecular Medicine
Volume95
Issue number4
DOIs
Publication statusPublished - Apr 1 2017

Keywords

  • Apoptosis
  • Chemoresistance
  • DNA repair
  • HMGA
  • miRNAs

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Genetics(clinical)

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