Abstract
OBJECTIVES: In 1966, Goldbloom et al. described two children who developed a peculiar clinical picture characterized by intermittent daily bone pain in the lower limbs, fever spikes, increased acute phase reactants and dysproteinaemia. The syndrome occurred two weeks after a group A β-haemolytic streptococcus infection. So far, only a few cases have been reported in the medical literature in English.
METHODS: We report two further cases of Goldbloom's syndrome with a review of the literature in English.
RESULTS: Our two patients lived in the same Italian region and presented their syndrome onset a week apart. Early use of STIR MRI revealed an atypical metaphyseal hyperintensity in the femurs and tibias. X-ray showed periosteal hyperostosis. A short cycle of corticosteroids led to rapid recovery of symptoms and disappearance of bone changes.
CONCLUSIONS: The reported cases highlight a likely under-recognised post-streptococcal inflammatory periosteal reaction and emphasise the diagnostic utility of the newer imaging modalities.
Original language | English |
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Pages (from-to) | 516-517 |
Number of pages | 2 |
Journal | Clinical and Experimental Rheumatology |
Volume | 35 |
Issue number | 3 |
Publication status | Published - Mar 25 2017 |
Keywords
- Adrenal Cortex Hormones
- Biomarkers
- Child
- Early Diagnosis
- Female
- Femur
- Humans
- Hypergammaglobulinemia
- Hypoalbuminemia
- Magnetic Resonance Imaging
- Periostitis
- Predictive Value of Tests
- Prednisone
- Streptococcal Infections
- Syndrome
- Tibia
- Treatment Outcome
- Case Reports
- Journal Article
- Review