OBJECTIVES: In 1966, Goldbloom et al. described two children who developed a peculiar clinical picture characterized by intermittent daily bone pain in the lower limbs, fever spikes, increased acute phase reactants and dysproteinaemia. The syndrome occurred two weeks after a group A β-haemolytic streptococcus infection. So far, only a few cases have been reported in the medical literature in English.
METHODS: We report two further cases of Goldbloom's syndrome with a review of the literature in English.
RESULTS: Our two patients lived in the same Italian region and presented their syndrome onset a week apart. Early use of STIR MRI revealed an atypical metaphyseal hyperintensity in the femurs and tibias. X-ray showed periosteal hyperostosis. A short cycle of corticosteroids led to rapid recovery of symptoms and disappearance of bone changes.
CONCLUSIONS: The reported cases highlight a likely under-recognised post-streptococcal inflammatory periosteal reaction and emphasise the diagnostic utility of the newer imaging modalities.
|Number of pages||2|
|Journal||Clinical and Experimental Rheumatology|
|Publication status||Published - Mar 25 2017|
- Adrenal Cortex Hormones
- Early Diagnosis
- Magnetic Resonance Imaging
- Predictive Value of Tests
- Streptococcal Infections
- Treatment Outcome
- Case Reports
- Journal Article