Critical role of STIR MRI in early detection of post-streptococcal periostitis with dysproteinaemia (Goldbloom's syndrome)

Research output: Contribution to journalReview articlepeer-review


OBJECTIVES: In 1966, Goldbloom et al. described two children who developed a peculiar clinical picture characterized by intermittent daily bone pain in the lower limbs, fever spikes, increased acute phase reactants and dysproteinaemia. The syndrome occurred two weeks after a group A β-haemolytic streptococcus infection. So far, only a few cases have been reported in the medical literature in English.

METHODS: We report two further cases of Goldbloom's syndrome with a review of the literature in English.

RESULTS: Our two patients lived in the same Italian region and presented their syndrome onset a week apart. Early use of STIR MRI revealed an atypical metaphyseal hyperintensity in the femurs and tibias. X-ray showed periosteal hyperostosis. A short cycle of corticosteroids led to rapid recovery of symptoms and disappearance of bone changes.

CONCLUSIONS: The reported cases highlight a likely under-recognised post-streptococcal inflammatory periosteal reaction and emphasise the diagnostic utility of the newer imaging modalities.

Original languageEnglish
Pages (from-to)516-517
Number of pages2
JournalClinical and Experimental Rheumatology
Issue number3
Publication statusPublished - Mar 25 2017


  • Adrenal Cortex Hormones
  • Biomarkers
  • Child
  • Early Diagnosis
  • Female
  • Femur
  • Humans
  • Hypergammaglobulinemia
  • Hypoalbuminemia
  • Magnetic Resonance Imaging
  • Periostitis
  • Predictive Value of Tests
  • Prednisone
  • Streptococcal Infections
  • Syndrome
  • Tibia
  • Treatment Outcome
  • Case Reports
  • Journal Article
  • Review


Dive into the research topics of 'Critical role of STIR MRI in early detection of post-streptococcal periostitis with dysproteinaemia (Goldbloom's syndrome)'. Together they form a unique fingerprint.

Cite this