Abstract
OBJECTIVES: In 1966, Goldbloom et al. described two children who developed a peculiar clinical picture characterized by intermittent daily bone pain in the lower limbs, fever spikes, increased acute phase reactants and dysproteinaemia. The syndrome occurred two weeks after a group A β-haemolytic streptococcus infection. So far, only a few cases have been reported in the medical literature in English.
METHODS: We report two further cases of Goldbloom's syndrome with a review of the literature in English.
RESULTS: Our two patients lived in the same Italian region and presented their syndrome onset a week apart. Early use of STIR MRI revealed an atypical metaphyseal hyperintensity in the femurs and tibias. X-ray showed periosteal hyperostosis. A short cycle of corticosteroids led to rapid recovery of symptoms and disappearance of bone changes.
CONCLUSIONS: The reported cases highlight a likely under-recognised post-streptococcal inflammatory periosteal reaction and emphasise the diagnostic utility of the newer imaging modalities.
| Original language | English |
|---|---|
| Pages (from-to) | 516-517 |
| Number of pages | 2 |
| Journal | Clinical and Experimental Rheumatology |
| Volume | 35 |
| Issue number | 3 |
| Publication status | Published - Mar 25 2017 |
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Keywords
- Adrenal Cortex Hormones
- Biomarkers
- Child
- Early Diagnosis
- Female
- Femur
- Humans
- Hypergammaglobulinemia
- Hypoalbuminemia
- Magnetic Resonance Imaging
- Periostitis
- Predictive Value of Tests
- Prednisone
- Streptococcal Infections
- Syndrome
- Tibia
- Treatment Outcome
- Case Reports
- Journal Article
- Review
Cite this
Critical role of STIR MRI in early detection of post-streptococcal periostitis with dysproteinaemia (Goldbloom's syndrome). / Papa, Riccardo; Consolaro, Alessandro; Minoia, Francesca; Caorsi, Roberta; Magnano, Gian Michele; Gattorno, Marco; Ravelli, Angelo; Picco, Paolo.
In: Clinical and Experimental Rheumatology, Vol. 35, No. 3, 25.03.2017, p. 516-517.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Critical role of STIR MRI in early detection of post-streptococcal periostitis with dysproteinaemia (Goldbloom's syndrome)
AU - Papa, Riccardo
AU - Consolaro, Alessandro
AU - Minoia, Francesca
AU - Caorsi, Roberta
AU - Magnano, Gian Michele
AU - Gattorno, Marco
AU - Ravelli, Angelo
AU - Picco, Paolo
PY - 2017/3/25
Y1 - 2017/3/25
N2 - OBJECTIVES: In 1966, Goldbloom et al. described two children who developed a peculiar clinical picture characterized by intermittent daily bone pain in the lower limbs, fever spikes, increased acute phase reactants and dysproteinaemia. The syndrome occurred two weeks after a group A β-haemolytic streptococcus infection. So far, only a few cases have been reported in the medical literature in English.METHODS: We report two further cases of Goldbloom's syndrome with a review of the literature in English.RESULTS: Our two patients lived in the same Italian region and presented their syndrome onset a week apart. Early use of STIR MRI revealed an atypical metaphyseal hyperintensity in the femurs and tibias. X-ray showed periosteal hyperostosis. A short cycle of corticosteroids led to rapid recovery of symptoms and disappearance of bone changes.CONCLUSIONS: The reported cases highlight a likely under-recognised post-streptococcal inflammatory periosteal reaction and emphasise the diagnostic utility of the newer imaging modalities.
AB - OBJECTIVES: In 1966, Goldbloom et al. described two children who developed a peculiar clinical picture characterized by intermittent daily bone pain in the lower limbs, fever spikes, increased acute phase reactants and dysproteinaemia. The syndrome occurred two weeks after a group A β-haemolytic streptococcus infection. So far, only a few cases have been reported in the medical literature in English.METHODS: We report two further cases of Goldbloom's syndrome with a review of the literature in English.RESULTS: Our two patients lived in the same Italian region and presented their syndrome onset a week apart. Early use of STIR MRI revealed an atypical metaphyseal hyperintensity in the femurs and tibias. X-ray showed periosteal hyperostosis. A short cycle of corticosteroids led to rapid recovery of symptoms and disappearance of bone changes.CONCLUSIONS: The reported cases highlight a likely under-recognised post-streptococcal inflammatory periosteal reaction and emphasise the diagnostic utility of the newer imaging modalities.
KW - Adrenal Cortex Hormones
KW - Biomarkers
KW - Child
KW - Early Diagnosis
KW - Female
KW - Femur
KW - Humans
KW - Hypergammaglobulinemia
KW - Hypoalbuminemia
KW - Magnetic Resonance Imaging
KW - Periostitis
KW - Predictive Value of Tests
KW - Prednisone
KW - Streptococcal Infections
KW - Syndrome
KW - Tibia
KW - Treatment Outcome
KW - Case Reports
KW - Journal Article
KW - Review
M3 - Review article
C2 - 28339360
VL - 35
SP - 516
EP - 517
JO - Clinical and Experimental Rheumatology
JF - Clinical and Experimental Rheumatology
SN - 0392-856X
IS - 3
ER -