Critical update and emerging trends in imatinib treatment for gastrointestinal stromal tumor

Ugo De Giorgi, Alberto Pupi, Gina Turrisi, Iolanda Montenora, Stefano Morini, Mozghan Fayyaz, Michele De Simone, Giammaria Fiorentini

Research output: Contribution to journalArticlepeer-review

Abstract

The extraordinary success of imatinib in gastrointestinal stromal tumor (GIST) represents a model for molecularly targeted therapy of solid tumors. Research is currently going to identify the molecular basis of mechanisms of action and drug resistance. For the optimal management of the patients treated, a multidisciplinary approach, including medical oncologists, surgeons, pathologists, and radiologists is needed. In this article, we reviewed recent advances in the clinical management of GIST patients treated with imatinib, and in the knowledge of the molecular mechanisms that are basic to imatinib effect.

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalReviews on Recent Clinical Trials
Volume2
Issue number1
DOIs
Publication statusPublished - Jan 2007

Keywords

  • Gastrointestinal stromal tumor
  • GIST
  • Imaging
  • Imatinib
  • KIT

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology

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