Critically ill patients: Immunological evidence of inflammation in muscle biopsy

P. Bazzi, M. Moggio, A. Prelle, M. Sciacco, S. Messina, S. Barbieri, P. Tonin, G. Tomelleri, A. Battistel, L. Adobbati, N. Checcarelli, G. Veschi, G. Scarlato

Research output: Contribution to journalArticle


Aim and method: To verify whether muscle necrosis in critically ill patients could be due to an inflammatory process, we tested muscle biopsies from five intensive care patients with different inflammation-specific immunocytochemical markers (antibodies anti-class I major histocompatibility complex products (class I MHCP or HLA I), membrane attack complex (MAC), T lymphocytes helper-inducer (CD4), cytotoxic (CD8) and pan-B-lymphocytes). Results: In three patients muscle biopsy showed class I MHCP positivity on the surface membrane of several groups of fibres, mainly perifascicular, and scattered microvascular deposits of MAC. In the other two patients muscle biopsy did not show class I MHCP and MAC positivity. Conclusion: Our results suggest that inflammation may be a component of muscle damage in some critically ill patients.

Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalClinical Neuropathology
Issue number1
Publication statusPublished - Jan 1999


  • Critical illness myopathy
  • Inflammation
  • Intensive care patients
  • Septic syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

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    Bazzi, P., Moggio, M., Prelle, A., Sciacco, M., Messina, S., Barbieri, S., Tonin, P., Tomelleri, G., Battistel, A., Adobbati, L., Checcarelli, N., Veschi, G., & Scarlato, G. (1999). Critically ill patients: Immunological evidence of inflammation in muscle biopsy. Clinical Neuropathology, 18(1), 23-30.