Abstract
In this work, bispectral and cross-bispectral analysis was applied to LFP and electromyographic (EMG) signals recorded in a patient with essential tremor, implanted in the subthalamic nucleus (STN) with DBS electrodes. Because the cross-bispectrum has sometimes a not plain interpretation, simulations were conducted to better understand the reliability of the estimation and to obtain a more detailed result interpretation. Both STN LFPs and the EMG had a predominant and highly coherent peak at 5Hz and a smaller peak at 10Hz. In addition, a high-beta activity (25-35 Hz) was detected in the STN. Whereas bispectral analysis on STN LFPs disclosed that STN rhythms are independent, cross-bispectral analysis disclosed a significant nonlinear synchronizations between LFPs and EMG, suggesting that the 5Hz subthalamic rhythm and the 5Hz muscular rhythm were non-linearly interacting and that this interaction produced at least part of the 10Hz oscillation in the EMG. The results of this work suggest that non-linear synchronizations between subcortical structures and peripheral muscles were found to have a role in the pathophysiology of tremor.
| Original language | English |
|---|---|
| Title of host publication | 2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09 |
| Pages | 494-497 |
| Number of pages | 4 |
| DOIs | |
| Publication status | Published - 2009 |
| Event | 2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09 - Antalya, Turkey Duration: Apr 29 2009 → May 2 2009 |
Other
| Other | 2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09 |
|---|---|
| Country | Turkey |
| City | Antalya |
| Period | 4/29/09 → 5/2/09 |
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Keywords
- Cross-bicoherence
- Cross-bispectral analysis
- Local field potentials
- Non-linear synchronization
ASJC Scopus subject areas
- Biomedical Engineering
- Clinical Neurology
- Neuroscience(all)
Cite this
Cross-bispectral analysis of local field potentials : An application to essential tremor. / Marceglia, Sara; Bianchi, Anna M.; Cerutti, Sergio; Servello, Domenico.
2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09. 2009. p. 494-497 5109341.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Cross-bispectral analysis of local field potentials
T2 - An application to essential tremor
AU - Marceglia, Sara
AU - Bianchi, Anna M.
AU - Cerutti, Sergio
AU - Servello, Domenico
PY - 2009
Y1 - 2009
N2 - In this work, bispectral and cross-bispectral analysis was applied to LFP and electromyographic (EMG) signals recorded in a patient with essential tremor, implanted in the subthalamic nucleus (STN) with DBS electrodes. Because the cross-bispectrum has sometimes a not plain interpretation, simulations were conducted to better understand the reliability of the estimation and to obtain a more detailed result interpretation. Both STN LFPs and the EMG had a predominant and highly coherent peak at 5Hz and a smaller peak at 10Hz. In addition, a high-beta activity (25-35 Hz) was detected in the STN. Whereas bispectral analysis on STN LFPs disclosed that STN rhythms are independent, cross-bispectral analysis disclosed a significant nonlinear synchronizations between LFPs and EMG, suggesting that the 5Hz subthalamic rhythm and the 5Hz muscular rhythm were non-linearly interacting and that this interaction produced at least part of the 10Hz oscillation in the EMG. The results of this work suggest that non-linear synchronizations between subcortical structures and peripheral muscles were found to have a role in the pathophysiology of tremor.
AB - In this work, bispectral and cross-bispectral analysis was applied to LFP and electromyographic (EMG) signals recorded in a patient with essential tremor, implanted in the subthalamic nucleus (STN) with DBS electrodes. Because the cross-bispectrum has sometimes a not plain interpretation, simulations were conducted to better understand the reliability of the estimation and to obtain a more detailed result interpretation. Both STN LFPs and the EMG had a predominant and highly coherent peak at 5Hz and a smaller peak at 10Hz. In addition, a high-beta activity (25-35 Hz) was detected in the STN. Whereas bispectral analysis on STN LFPs disclosed that STN rhythms are independent, cross-bispectral analysis disclosed a significant nonlinear synchronizations between LFPs and EMG, suggesting that the 5Hz subthalamic rhythm and the 5Hz muscular rhythm were non-linearly interacting and that this interaction produced at least part of the 10Hz oscillation in the EMG. The results of this work suggest that non-linear synchronizations between subcortical structures and peripheral muscles were found to have a role in the pathophysiology of tremor.
KW - Cross-bicoherence
KW - Cross-bispectral analysis
KW - Local field potentials
KW - Non-linear synchronization
UR - http://www.scopus.com/inward/record.url?scp=70350236582&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350236582&partnerID=8YFLogxK
U2 - 10.1109/NER.2009.5109341
DO - 10.1109/NER.2009.5109341
M3 - Conference contribution
SN - 9781424420735
SP - 494
EP - 497
BT - 2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09
ER -