Cross-bispectral analysis of local field potentials: An application to essential tremor

Sara Marceglia, Anna M. Bianchi, Sergio Cerutti, Domenico Servello

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this work, bispectral and cross-bispectral analysis was applied to LFP and electromyographic (EMG) signals recorded in a patient with essential tremor, implanted in the subthalamic nucleus (STN) with DBS electrodes. Because the cross-bispectrum has sometimes a not plain interpretation, simulations were conducted to better understand the reliability of the estimation and to obtain a more detailed result interpretation. Both STN LFPs and the EMG had a predominant and highly coherent peak at 5Hz and a smaller peak at 10Hz. In addition, a high-beta activity (25-35 Hz) was detected in the STN. Whereas bispectral analysis on STN LFPs disclosed that STN rhythms are independent, cross-bispectral analysis disclosed a significant nonlinear synchronizations between LFPs and EMG, suggesting that the 5Hz subthalamic rhythm and the 5Hz muscular rhythm were non-linearly interacting and that this interaction produced at least part of the 10Hz oscillation in the EMG. The results of this work suggest that non-linear synchronizations between subcortical structures and peripheral muscles were found to have a role in the pathophysiology of tremor.

Original languageEnglish
Title of host publication2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09
Pages494-497
Number of pages4
DOIs
Publication statusPublished - 2009
Event2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09 - Antalya, Turkey
Duration: Apr 29 2009May 2 2009

Other

Other2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09
CountryTurkey
CityAntalya
Period4/29/095/2/09

Keywords

  • Cross-bicoherence
  • Cross-bispectral analysis
  • Local field potentials
  • Non-linear synchronization

ASJC Scopus subject areas

  • Biomedical Engineering
  • Clinical Neurology
  • Neuroscience(all)

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    Marceglia, S., Bianchi, A. M., Cerutti, S., & Servello, D. (2009). Cross-bispectral analysis of local field potentials: An application to essential tremor. In 2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09 (pp. 494-497). [5109341] https://doi.org/10.1109/NER.2009.5109341