Abstract
In this work, bispectral and cross-bispectral analysis was applied to LFP and electromyographic (EMG) signals recorded in a patient with essential tremor, implanted in the subthalamic nucleus (STN) with DBS electrodes. Because the cross-bispectrum has sometimes a not plain interpretation, simulations were conducted to better understand the reliability of the estimation and to obtain a more detailed result interpretation. Both STN LFPs and the EMG had a predominant and highly coherent peak at 5Hz and a smaller peak at 10Hz. In addition, a high-beta activity (25-35 Hz) was detected in the STN. Whereas bispectral analysis on STN LFPs disclosed that STN rhythms are independent, cross-bispectral analysis disclosed a significant nonlinear synchronizations between LFPs and EMG, suggesting that the 5Hz subthalamic rhythm and the 5Hz muscular rhythm were non-linearly interacting and that this interaction produced at least part of the 10Hz oscillation in the EMG. The results of this work suggest that non-linear synchronizations between subcortical structures and peripheral muscles were found to have a role in the pathophysiology of tremor.
Original language | English |
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Title of host publication | 2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09 |
Pages | 494-497 |
Number of pages | 4 |
DOIs | |
Publication status | Published - 2009 |
Event | 2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09 - Antalya, Turkey Duration: Apr 29 2009 → May 2 2009 |
Other
Other | 2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09 |
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Country/Territory | Turkey |
City | Antalya |
Period | 4/29/09 → 5/2/09 |
Keywords
- Cross-bicoherence
- Cross-bispectral analysis
- Local field potentials
- Non-linear synchronization
ASJC Scopus subject areas
- Biomedical Engineering
- Clinical Neurology
- Neuroscience(all)