Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 57-62 |
| Number of pages | 6 |
| Journal | Radiotherapy and Oncology |
| Volume | 123 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Apr 1 2017 |
Fingerprint
Keywords
- APE
- IMRT
- KBP
- OVH
Cite this
Cross-institutional knowledge-based planning (KBP) implementation and its performance comparison to Auto-Planning Engine (APE). / Wu, B.; Kusters, M.; Kunze-Busch, M.; Dijkema, T.; McNutt, T.; Sanguineti, G.; Bzdusek, K.; Dritschilo, A.; Pang, D.
In: Radiotherapy and Oncology, Vol. 123, No. 1, 01.04.2017, p. 57-62.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cross-institutional knowledge-based planning (KBP) implementation and its performance comparison to Auto-Planning Engine (APE)
AU - Wu, B.
AU - Kusters, M.
AU - Kunze-Busch, M.
AU - Dijkema, T.
AU - McNutt, T.
AU - Sanguineti, G.
AU - Bzdusek, K.
AU - Dritschilo, A.
AU - Pang, D.
N1 - LR: 20170410; CI: Copyright (c) 2017; JID: 8407192; OTO: NOTNLM; 2016/08/29 [received]; 2017/01/19 [revised]; 2017/01/21 [accepted]; ppublish
PY - 2017/4/1
Y1 - 2017/4/1
N2 - BACKGROUND AND PURPOSE: To investigate (1) whether a plan library established at one institution can be applied for another institution's knowledge-based planning (KBP); (2) the performance of cross-institutional KBP compared to Auto-Planning Engine (APE). MATERIAL AND METHODS: Radboud University Medical Center (RUMC) provided 35 oropharyngeal cancer patients (68Gy to PTV68 and 50.3Gy to PTV50.3) with clinically-delivered and comparative APE plans. The Johns Hopkins University (JHU) contributed a three-dose-level plan library consisting of 179 clinically-delivered plans. MedStar Georgetown University Hospital (MGUH) contributed a KBP approach employing overlap-volume histogram (OVH-KBP), where the JHU library was used for guiding RUMC patients' KBP. Since clinical protocols adopted at RUMC and JHU are different and both approaches require protocol-specific planning parameters as initial input, 10 randomly selected patients from RUMC were set aside for deriving them. The finalized parameters were applied to the remaining 25 patients for OVH-KBP and APE plan generation. A Wilcoxon rank-sum test was used for statistical comparison. RESULTS: PTV68 and PTV50.3's V95 in OVH-KBP and APE were similar (p>0.36). Cord's D0.1 cc in OVH-KBP was reduced by 5.1Gy (p=0.0001); doses to other organs were similar (p>0.2). CONCLUSION: APE and OVH-KBP's plan quality is comparable. Institutional-protocol differences can be addressed to allow cross-institutional library sharing.
AB - BACKGROUND AND PURPOSE: To investigate (1) whether a plan library established at one institution can be applied for another institution's knowledge-based planning (KBP); (2) the performance of cross-institutional KBP compared to Auto-Planning Engine (APE). MATERIAL AND METHODS: Radboud University Medical Center (RUMC) provided 35 oropharyngeal cancer patients (68Gy to PTV68 and 50.3Gy to PTV50.3) with clinically-delivered and comparative APE plans. The Johns Hopkins University (JHU) contributed a three-dose-level plan library consisting of 179 clinically-delivered plans. MedStar Georgetown University Hospital (MGUH) contributed a KBP approach employing overlap-volume histogram (OVH-KBP), where the JHU library was used for guiding RUMC patients' KBP. Since clinical protocols adopted at RUMC and JHU are different and both approaches require protocol-specific planning parameters as initial input, 10 randomly selected patients from RUMC were set aside for deriving them. The finalized parameters were applied to the remaining 25 patients for OVH-KBP and APE plan generation. A Wilcoxon rank-sum test was used for statistical comparison. RESULTS: PTV68 and PTV50.3's V95 in OVH-KBP and APE were similar (p>0.36). Cord's D0.1 cc in OVH-KBP was reduced by 5.1Gy (p=0.0001); doses to other organs were similar (p>0.2). CONCLUSION: APE and OVH-KBP's plan quality is comparable. Institutional-protocol differences can be addressed to allow cross-institutional library sharing.
KW - APE
KW - IMRT
KW - KBP
KW - OVH
U2 - S0167-8140(17)30037-3 [pii]
DO - S0167-8140(17)30037-3 [pii]
M3 - Article
VL - 123
SP - 57
EP - 62
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
SN - 0167-8140
IS - 1
ER -