Cross-linking of CD30 induces HIV expression in chronically infected T cells

Priscilla Blswas, Craig A. Smith, Delta Goletti, Elena C. Hardy, Robert W. Jackson, Anthony S. Fauci

Research output: Contribution to journalArticle

Abstract

CD30, a member of the tumor necrosis factor (TNF) receptor family, is expressed constitutively on the surface of the human T cell line ACH-2, which is chronically infected with human Immunodeficiency virus type-1 (HIV)-1. We demonstrate that cross-linking CD30 with an anti-CD30-specific monoclonal antibody, which mimics the described biological activities of the CD30 ligand (CD30L), results in HIV expression. CD30 cross-linking does not alter proliferation of ACH-2 cells and the induction of HIV expression is not mediated by endogenous TNFα/β. Furthermore, cross-linking of CD30 leads to NF-κB activation and enhanced HIV transcription. Thus, CD30-CD30L Interactions mediate the induction of HIV expression by a κB-dependent path-way that is Independent of TNF. This mechanism may be Important In the activation of HIV expression from latently Infected CD4+ T cells, especially in lymphoid organs where cell to cell contact is conducive to receptor-ligand interactions.

Original languageEnglish
Pages (from-to)587-596
Number of pages10
JournalImmunity
Volume2
Issue number6
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Infectious Diseases

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    Blswas, P., Smith, C. A., Goletti, D., Hardy, E. C., Jackson, R. W., & Fauci, A. S. (1995). Cross-linking of CD30 induces HIV expression in chronically infected T cells. Immunity, 2(6), 587-596. https://doi.org/10.1016/1074-7613(95)90003-9