Cross-protection by MF59™-adjuvanted influenza vaccine: Neutralizing and haemagglutination-inhibiting antibody activity against A(H3N2) drifted influenza viruses

Filippo Ansaldi, Sabrina Bacilieri, Paolo Durando, Laura Sticchi, Laura Valle, Emanuele Montomoli, Giancarlo Icardi, Roberto Gasparini, Pietro Crovari

Research output: Contribution to journalArticle

Abstract

Adjuvants enhance antibody response against vaccination. We compared the ability of MF59™-adjuvanted and non-adjuvanted subunit influenza vaccines, containing A/Wyoming/3/03(H3N2), to confer cross-protection against four consecutive drifted strains in the elderly. Neutralizing and haemagglutination-inhibiting antibody were measured. MF59™-adjuvanted vaccine induced a stronger booster response against A/Panama/2007/99(H3N2) than non-adjuvanted vaccine. A/Panama/2007/99(H3N2) circulated widely during the previous 5 years and was included in vaccines over four consecutive seasons. Broader serological protection against drifted strains that circulated 1 and 2 years after vaccination with A/Wyoming/3/03(H3N2) was observed with MF59™-adjuvanted vaccine. Thus, MF59™-adjuvanted vaccine confers greater immunogenicity than non-adjuvanted vaccines in vulnerable populations.

Original languageEnglish
Pages (from-to)1525-1529
Number of pages5
JournalVaccine
Volume26
Issue number12
DOIs
Publication statusPublished - Mar 17 2008

Fingerprint

Cross Protection
Influenza Vaccines
Hemagglutination
Orthomyxoviridae
hemagglutination
neutralization
influenza
Vaccines
vaccines
antibodies
Antibodies
Panama
Vaccination
vaccination
Subunit Vaccines
Vulnerable Populations
Antibody Formation
MF59 oil emulsion
adjuvants
immune response

Keywords

  • Antigenic drift
  • Cross-protection
  • Influenza
  • MF59™

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Cross-protection by MF59™-adjuvanted influenza vaccine : Neutralizing and haemagglutination-inhibiting antibody activity against A(H3N2) drifted influenza viruses. / Ansaldi, Filippo; Bacilieri, Sabrina; Durando, Paolo; Sticchi, Laura; Valle, Laura; Montomoli, Emanuele; Icardi, Giancarlo; Gasparini, Roberto; Crovari, Pietro.

In: Vaccine, Vol. 26, No. 12, 17.03.2008, p. 1525-1529.

Research output: Contribution to journalArticle

Ansaldi, F, Bacilieri, S, Durando, P, Sticchi, L, Valle, L, Montomoli, E, Icardi, G, Gasparini, R & Crovari, P 2008, 'Cross-protection by MF59™-adjuvanted influenza vaccine: Neutralizing and haemagglutination-inhibiting antibody activity against A(H3N2) drifted influenza viruses', Vaccine, vol. 26, no. 12, pp. 1525-1529. https://doi.org/10.1016/j.vaccine.2008.01.019
Ansaldi, Filippo ; Bacilieri, Sabrina ; Durando, Paolo ; Sticchi, Laura ; Valle, Laura ; Montomoli, Emanuele ; Icardi, Giancarlo ; Gasparini, Roberto ; Crovari, Pietro. / Cross-protection by MF59™-adjuvanted influenza vaccine : Neutralizing and haemagglutination-inhibiting antibody activity against A(H3N2) drifted influenza viruses. In: Vaccine. 2008 ; Vol. 26, No. 12. pp. 1525-1529.
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