Cross-reactive response to human immunodeficiency virus type 1 (HIV-1) gp120 and HLA class I heavy chains induced by receipt of HIV-1-derived envelope vaccines

C. De Santis, P. Robbioni, R. Longhi, L. Lopalco, A. G. Siccardi, A. Beretta, N. J. Roberts

Research output: Contribution to journalArticlepeer-review

Abstract

Autoantibodies specific to HLA class I antigens were detected in the sera of persons vaccinated with human immunodeficiency virus type 1-derived recombinant vaccines by using synthetic peptides representing the amino acid sequences recognized by an HLA class I/gp120 cross-reactive monoclonal antibody. Study subjects received recombinant vaccinia gp160 (vacc-env) alone, vacc-env followed by one dose of recombinant gp160 (rgp160, 640 μg), or four doses of rgp160 alone (640 or 80 μg). All sera from vacc-env/rgp160- vaccinated subjects contained HLA/gp120 cross-reactive antibodies, as did all sera from recipients of the rgp160 alone at 640 μg/dose. In contrast, none of the sera from subjects who received either the vacc-env alone or the 80 μg/dose rgp160 alone contained detectable HLA cross-reactive antibodies, and these same sera showed little or no envelope reactivity on Western blot. The results showed a striking correlation between immunogenicity and the induction of cross-reactive antibodies by the rgp160 vaccine.

Original languageEnglish
Pages (from-to)1396-1403
Number of pages8
JournalJournal of Infectious Diseases
Volume168
Issue number6
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

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