TY - JOUR
T1 - Cross-resistance profile of the novel integrase inhibitor dolutegravir (S/GSK1349572) using clonal viral variants selected in patients failing raltegravir
AU - Canducci, Filippo
AU - Ceresola, Elisa R.
AU - Boeri, Enzo
AU - Spagnuolo, Vincenzo
AU - Cossarini, Francesca
AU - Castagna, Antonella
AU - Lazzarin, Adriano
AU - Clementi, Massimo
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Novel integrase inhibitors are in advanced clinical development, and cross-resistance data are needed to consider the possibility to plan a sequential usage within this class of antiretroviral drugs. Ex vivo phenotypic assays were conducted on 11 wild-type and 27 fully replicating recombinant viruses obtained from 11 patients failing previous raltegravir-containing regimens. Dolutegravir maintained its activity in vitro on viruses with mutations in position 143 and 155. However, viruses with mutation Q148R associated with secondary mutations and the combination Q148H+G140S were instead associated with a reduced level of susceptibility to dolutegravir in vitro.
AB - Novel integrase inhibitors are in advanced clinical development, and cross-resistance data are needed to consider the possibility to plan a sequential usage within this class of antiretroviral drugs. Ex vivo phenotypic assays were conducted on 11 wild-type and 27 fully replicating recombinant viruses obtained from 11 patients failing previous raltegravir-containing regimens. Dolutegravir maintained its activity in vitro on viruses with mutations in position 143 and 155. However, viruses with mutation Q148R associated with secondary mutations and the combination Q148H+G140S were instead associated with a reduced level of susceptibility to dolutegravir in vitro.
UR - http://www.scopus.com/inward/record.url?scp=80155188567&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80155188567&partnerID=8YFLogxK
U2 - 10.1093/infdis/jir636
DO - 10.1093/infdis/jir636
M3 - Article
C2 - 21984737
AN - SCOPUS:80155188567
VL - 204
SP - 1811
EP - 1815
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 11
ER -