TY - JOUR
T1 - Cross-sectional associations between air pollution and chronic bronchitis
T2 - An ESCAPE meta-analysis across five cohorts
AU - Cai, Yutong
AU - Schikowski, Tamara
AU - Adam, Martin
AU - Buschka, Anna
AU - Carsin, Anne Elie
AU - Jacquemin, Benedicte
AU - Marcon, Alessandro
AU - Sanchez, Margaux
AU - Vierkötter, Andrea
AU - Al-Kanaani, Zaina
AU - Beelen, Rob
AU - Birk, Matthias
AU - Brunekreef, Bert
AU - Cirach, Marta
AU - Clavel-Chapelon, Franc¸oise
AU - Declercq, Christophe
AU - De Hoogh, Kees
AU - De Nazelle, Audrey
AU - Ducret-Stich, Regina E.
AU - Ferretti, Virginia Valeria
AU - Forsberg, Bertil
AU - Gerbase, Margaret W.
AU - Hardy, Rebecca
AU - Heinrich, Joachim
AU - Hoek, Gerard
AU - Jarvis, Debbie
AU - Keidel, Dirk
AU - Kuh, Diana
AU - Nieuwenhuijsen, Mark J.
AU - Ragettli, Martina S.
AU - Ranzi, Andrea
AU - Rochat, Thierry
AU - Schindler, Christian
AU - Sugiri, Dorothea
AU - Temam, Sofia
AU - Tsai, Ming Yi
AU - Varraso, Raphaëlle
AU - Kauffmann, Francine
AU - Krämer, Ursula
AU - Sunyer, Jordi
AU - Künzli, Nino
AU - Probst-Hensch, Nicole
AU - Hansell, Anna L.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Background: This study aimed to assess associations of outdoor air pollution on prevalence of chronic bronchitis symptoms in adults in fi ve cohort studies (Asthma-E3N, ECRHS, NSHD, SALIA, SAPALDIA) participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE) project. Methods: Annual average particulate matter (PM10, PM2.5, PMabsorbance, PMcoarse), NO2, nitrogen oxides (NOx) and road traffic measures modelled from ESCAPE measurement campaigns 2008-2011 were assigned to home address at most recent assessments (1998-2011). Symptoms examined were chronic bronchitis (cough and phlegm for ≥3 months of the year for ≥2 years), chronic cough (with/without phlegm) and chronic phlegm (with/without cough). Cohort-speci fic cross-sectional multivariable logistic regression analyses were conducted using common confounder sets (age, sex, smoking, interview season, education), followed by meta-analysis. Results: 15 279 and 10 537 participants respectively were included in the main NO2and PM analyses at assessments in 1998-2011. Overall, there were no statistically significant associations with any air pollutant or traffic exposure. Sensitivity analyses including in asthmatics only, females only or using back-extrapolated NO2and PM10for assessments in 1985-2002 (ECRHS, NSHD, SALIA, SAPALDIA) did not alter conclusions. In never-smokers, all associations were positive, but reached statistical significance only for chronic phlegm with PMcoarseOR 1.31 (1.05 to 1.64) per 5 μg/m3increase and PM10with similar effect size. Sensitivity analyses of older cohorts showed increased risk of chronic cough with PM2.5abs(black carbon) exposures. Conclusions: Results do not show consistent associations between chronic bronchitis symptoms and current traffic-related air pollution in adult European populations.
AB - Background: This study aimed to assess associations of outdoor air pollution on prevalence of chronic bronchitis symptoms in adults in fi ve cohort studies (Asthma-E3N, ECRHS, NSHD, SALIA, SAPALDIA) participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE) project. Methods: Annual average particulate matter (PM10, PM2.5, PMabsorbance, PMcoarse), NO2, nitrogen oxides (NOx) and road traffic measures modelled from ESCAPE measurement campaigns 2008-2011 were assigned to home address at most recent assessments (1998-2011). Symptoms examined were chronic bronchitis (cough and phlegm for ≥3 months of the year for ≥2 years), chronic cough (with/without phlegm) and chronic phlegm (with/without cough). Cohort-speci fic cross-sectional multivariable logistic regression analyses were conducted using common confounder sets (age, sex, smoking, interview season, education), followed by meta-analysis. Results: 15 279 and 10 537 participants respectively were included in the main NO2and PM analyses at assessments in 1998-2011. Overall, there were no statistically significant associations with any air pollutant or traffic exposure. Sensitivity analyses including in asthmatics only, females only or using back-extrapolated NO2and PM10for assessments in 1985-2002 (ECRHS, NSHD, SALIA, SAPALDIA) did not alter conclusions. In never-smokers, all associations were positive, but reached statistical significance only for chronic phlegm with PMcoarseOR 1.31 (1.05 to 1.64) per 5 μg/m3increase and PM10with similar effect size. Sensitivity analyses of older cohorts showed increased risk of chronic cough with PM2.5abs(black carbon) exposures. Conclusions: Results do not show consistent associations between chronic bronchitis symptoms and current traffic-related air pollution in adult European populations.
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U2 - 10.1136/thoraxjnl-2013-204352
DO - 10.1136/thoraxjnl-2013-204352
M3 - Article
C2 - 25112730
AN - SCOPUS:84907891191
VL - 69
SP - 1005
EP - 1014
JO - Thorax
JF - Thorax
SN - 0040-6376
IS - 11
ER -