Abstract
It is important to understand which molecules are relevant for linking innate and adaptive immune cells. In this study, we show that OX40 ligand is selectively induced on IL-2, IL-12, or IL-15-activated human NK cells following stimulation through NKG2D, the low affinity receptor for IgG (CD16) or killer cell Ig-like receptor 2DS2. CD16-activated NK cells costimulate TCR-induced proliferation, and IFN-γ produced by autologous CD4+ T cells and this process is dependent upon expression of OX46 ligand and B7 by the activated NK cells. These findings suggest a novel and unexpected link between the natural and specific immune responses, providing direct evidence for cross-talk between human CD4+ T cells and NK receptor-activated NK cells.
| Original language | English |
|---|---|
| Pages (from-to) | 3716-3724 |
| Number of pages | 9 |
| Journal | Journal of Immunology |
| Volume | 173 |
| Issue number | 6 |
| Publication status | Published - Sep 15 2004 |
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ASJC Scopus subject areas
- Immunology
Cite this
Cross-talk between activated human NK cells and CD4+ T cells via OX40-OX40 ligand interactions. / Zingoni, Alessandra; Sornasse, Thierry; Cocks, Benjamin G.; Tanaka, Yuetsu; Santoni, Angela; Lanier, Lewis L.
In: Journal of Immunology, Vol. 173, No. 6, 15.09.2004, p. 3716-3724.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cross-talk between activated human NK cells and CD4+ T cells via OX40-OX40 ligand interactions
AU - Zingoni, Alessandra
AU - Sornasse, Thierry
AU - Cocks, Benjamin G.
AU - Tanaka, Yuetsu
AU - Santoni, Angela
AU - Lanier, Lewis L.
PY - 2004/9/15
Y1 - 2004/9/15
N2 - It is important to understand which molecules are relevant for linking innate and adaptive immune cells. In this study, we show that OX40 ligand is selectively induced on IL-2, IL-12, or IL-15-activated human NK cells following stimulation through NKG2D, the low affinity receptor for IgG (CD16) or killer cell Ig-like receptor 2DS2. CD16-activated NK cells costimulate TCR-induced proliferation, and IFN-γ produced by autologous CD4+ T cells and this process is dependent upon expression of OX46 ligand and B7 by the activated NK cells. These findings suggest a novel and unexpected link between the natural and specific immune responses, providing direct evidence for cross-talk between human CD4+ T cells and NK receptor-activated NK cells.
AB - It is important to understand which molecules are relevant for linking innate and adaptive immune cells. In this study, we show that OX40 ligand is selectively induced on IL-2, IL-12, or IL-15-activated human NK cells following stimulation through NKG2D, the low affinity receptor for IgG (CD16) or killer cell Ig-like receptor 2DS2. CD16-activated NK cells costimulate TCR-induced proliferation, and IFN-γ produced by autologous CD4+ T cells and this process is dependent upon expression of OX46 ligand and B7 by the activated NK cells. These findings suggest a novel and unexpected link between the natural and specific immune responses, providing direct evidence for cross-talk between human CD4+ T cells and NK receptor-activated NK cells.
UR - http://www.scopus.com/inward/record.url?scp=4644303421&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4644303421&partnerID=8YFLogxK
M3 - Article
VL - 173
SP - 3716
EP - 3724
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 6
ER -