Abstract
It is important to understand which molecules are relevant for linking innate and adaptive immune cells. In this study, we show that OX40 ligand is selectively induced on IL-2, IL-12, or IL-15-activated human NK cells following stimulation through NKG2D, the low affinity receptor for IgG (CD16) or killer cell Ig-like receptor 2DS2. CD16-activated NK cells costimulate TCR-induced proliferation, and IFN-γ produced by autologous CD4+ T cells and this process is dependent upon expression of OX46 ligand and B7 by the activated NK cells. These findings suggest a novel and unexpected link between the natural and specific immune responses, providing direct evidence for cross-talk between human CD4+ T cells and NK receptor-activated NK cells.
Original language | English |
---|---|
Pages (from-to) | 3716-3724 |
Number of pages | 9 |
Journal | Journal of Immunology |
Volume | 173 |
Issue number | 6 |
Publication status | Published - Sep 15 2004 |
ASJC Scopus subject areas
- Immunology