Cross-talk between Epstein-Barr virus and microenvironment in the pathogenesis of lymphomas

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Epstein-Bar virus (EBV) is known to directly drive the neoplastic transformation of lymphoid cells resulting in the development of a variety of lymphoproliferative disorders. Emerging evidence however indicates that this final outcome is also related to the ability of EBV to shape microenvironment making it more conducive to cell transformation. Indeed, EBV up-regulates the production of several soluble factors promoting the growth and/or the survival of lymphoid cells and orchestrates a variety of complex mechanisms favoring their escape from anti-tumor immune responses. Furthermore, EBV-infected B lymphocytes actively secrete exosomes and recent investigation is now shedding light on the content and functional impact that these bioactive vesicles may have in bystander recipient cells. The complex interplay existing between EBV-carrying lymphoid cells and tumor microenvironment is now offering attractive targets of therapy that can be exploited to improve current therapeutic strategies for EBV-driven lymphoid malignancies.

Original languageEnglish
Pages (from-to)58-69
Number of pages12
JournalSeminars in Cancer Biology
Volume34
DOIs
Publication statusPublished - Oct 1 2015

Fingerprint

Human Herpesvirus 4
Lymphoma
Viruses
Lymphocytes
Tumor Escape
Exosomes
Cellular Microenvironment
Tumor Microenvironment
Lymphoproliferative Disorders
Intercellular Signaling Peptides and Proteins
B-Lymphocytes
Up-Regulation
Therapeutics
Neoplasms

Keywords

  • Epstein-Barr virus
  • Exosome
  • Immune response
  • Lymphoma
  • Microenvironment

ASJC Scopus subject areas

  • Cancer Research

Cite this

Cross-talk between Epstein-Barr virus and microenvironment in the pathogenesis of lymphomas. / Dolcetti, Riccardo.

In: Seminars in Cancer Biology, Vol. 34, 01.10.2015, p. 58-69.

Research output: Contribution to journalArticle

@article{9a876ec432214b53830885c1d94c81a3,
title = "Cross-talk between Epstein-Barr virus and microenvironment in the pathogenesis of lymphomas",
abstract = "Epstein-Bar virus (EBV) is known to directly drive the neoplastic transformation of lymphoid cells resulting in the development of a variety of lymphoproliferative disorders. Emerging evidence however indicates that this final outcome is also related to the ability of EBV to shape microenvironment making it more conducive to cell transformation. Indeed, EBV up-regulates the production of several soluble factors promoting the growth and/or the survival of lymphoid cells and orchestrates a variety of complex mechanisms favoring their escape from anti-tumor immune responses. Furthermore, EBV-infected B lymphocytes actively secrete exosomes and recent investigation is now shedding light on the content and functional impact that these bioactive vesicles may have in bystander recipient cells. The complex interplay existing between EBV-carrying lymphoid cells and tumor microenvironment is now offering attractive targets of therapy that can be exploited to improve current therapeutic strategies for EBV-driven lymphoid malignancies.",
keywords = "Epstein-Barr virus, Exosome, Immune response, Lymphoma, Microenvironment",
author = "Riccardo Dolcetti",
year = "2015",
month = "10",
day = "1",
doi = "10.1016/j.semcancer.2015.04.006",
language = "English",
volume = "34",
pages = "58--69",
journal = "Seminars in Cancer Biology",
issn = "1044-579X",
publisher = "Academic Press",

}

TY - JOUR

T1 - Cross-talk between Epstein-Barr virus and microenvironment in the pathogenesis of lymphomas

AU - Dolcetti, Riccardo

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Epstein-Bar virus (EBV) is known to directly drive the neoplastic transformation of lymphoid cells resulting in the development of a variety of lymphoproliferative disorders. Emerging evidence however indicates that this final outcome is also related to the ability of EBV to shape microenvironment making it more conducive to cell transformation. Indeed, EBV up-regulates the production of several soluble factors promoting the growth and/or the survival of lymphoid cells and orchestrates a variety of complex mechanisms favoring their escape from anti-tumor immune responses. Furthermore, EBV-infected B lymphocytes actively secrete exosomes and recent investigation is now shedding light on the content and functional impact that these bioactive vesicles may have in bystander recipient cells. The complex interplay existing between EBV-carrying lymphoid cells and tumor microenvironment is now offering attractive targets of therapy that can be exploited to improve current therapeutic strategies for EBV-driven lymphoid malignancies.

AB - Epstein-Bar virus (EBV) is known to directly drive the neoplastic transformation of lymphoid cells resulting in the development of a variety of lymphoproliferative disorders. Emerging evidence however indicates that this final outcome is also related to the ability of EBV to shape microenvironment making it more conducive to cell transformation. Indeed, EBV up-regulates the production of several soluble factors promoting the growth and/or the survival of lymphoid cells and orchestrates a variety of complex mechanisms favoring their escape from anti-tumor immune responses. Furthermore, EBV-infected B lymphocytes actively secrete exosomes and recent investigation is now shedding light on the content and functional impact that these bioactive vesicles may have in bystander recipient cells. The complex interplay existing between EBV-carrying lymphoid cells and tumor microenvironment is now offering attractive targets of therapy that can be exploited to improve current therapeutic strategies for EBV-driven lymphoid malignancies.

KW - Epstein-Barr virus

KW - Exosome

KW - Immune response

KW - Lymphoma

KW - Microenvironment

UR - http://www.scopus.com/inward/record.url?scp=84942297160&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942297160&partnerID=8YFLogxK

U2 - 10.1016/j.semcancer.2015.04.006

DO - 10.1016/j.semcancer.2015.04.006

M3 - Article

C2 - 25953434

AN - SCOPUS:84942297160

VL - 34

SP - 58

EP - 69

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

SN - 1044-579X

ER -