Cross-talk between hematopoiesis and angiogenesis signaling pathways

Domenico Ribatti, Angelo Vacca, Beatrice Nico, Roberto Ria, Franco Dammacco

Research output: Contribution to journalArticlepeer-review


The relationship between hematopoietic cells and endothelial cells has been seen as an indication that a common progenitor, the hemangioblast, gives rise to both cell types in the yolk sac, the initial site of hematopoiesis and blood vessel formation during mammalian development. The existence of angioblast-like circulating endothelial precursor cells in adults humans has recently been suggested. In this review, we have summarized the principle mechanisms involved in the cross-talk signaling pathway between hematopoiesis and angiogenesis in order to further understand how the hematopoietic and vascular systems are established during the development.

Original languageEnglish
Pages (from-to)537-543
Number of pages7
JournalCurrent Molecular Medicine
Issue number6
Publication statusPublished - Sep 2002


  • Angiogenesis
  • Endothelial precursor cells
  • Hematopoiesis
  • Signaling pathway

ASJC Scopus subject areas

  • Biochemistry


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