Abstract
The relationship between hematopoietic cells and endothelial cells has been seen as an indication that a common progenitor, the hemangioblast, gives rise to both cell types in the yolk sac, the initial site of hematopoiesis and blood vessel formation during mammalian development. The existence of angioblast-like circulating endothelial precursor cells in adults humans has recently been suggested. In this review, we have summarized the principle mechanisms involved in the cross-talk signaling pathway between hematopoiesis and angiogenesis in order to further understand how the hematopoietic and vascular systems are established during the development.
Original language | English |
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Pages (from-to) | 537-543 |
Number of pages | 7 |
Journal | Current Molecular Medicine |
Volume | 2 |
Issue number | 6 |
DOIs | |
Publication status | Published - Sep 2002 |
Keywords
- Angiogenesis
- Endothelial precursor cells
- Hematopoiesis
- Signaling pathway
ASJC Scopus subject areas
- Biochemistry