Crosstalk among p53 family members in cutaneous carcinoma

Caterina Missero, Dario Antonini

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Cutaneous squamous cell carcinoma (cSCC) is the second most common human cancer with a frequency increasing worldwide. The risk of developing cSCC has been strongly associated with chronic sun exposure, especially in light skin people. The aim of this viewpoint is to discuss the contribution of the tumor suppressor p53 and its homologues p63 and p73 in the formation and progression of cSCC. Mutations in the p53 gene are early and frequent events in skin carcinogenesis mainly as a consequence of UV light exposure, often followed by loss of function of the second allele. Although rarely mutated in cancer, p63 and p73 play key roles in human cancers, with their truncated isoforms lacking the N-terminal transactivating domain ({increment}N) being often upregulated as compared to normal tissues. {increment}Np63 is abundantly expressed in cSCC, and it is likely to favour tumor initiation and progression. The function of p73 in cSCC is more enigmatic and awaits further studies. Interestingly, an intimate interplay exists between both p53 and p63, and the Notch signalling pathway, often inactivated in cSCC. Here, we summarize our current knowledge about the biological activities of p53 family members in cSCC and propose that integration of their signalling with Notch is key to cSCC formation and progression.

Original languageEnglish
Pages (from-to)143-146
Number of pages4
JournalExperimental Dermatology
Volume23
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

Crosstalk
Squamous Cell Carcinoma
Carcinoma
Skin
Tumors
Neoplasms
Epithelial Cells
Bioactivity
Ultraviolet radiation
Sun
p53 Genes
Solar System
Ultraviolet Rays
Protein Isoforms
Genes
Tissue
Carcinogenesis
Alleles
Light
Mutation

Keywords

  • Mouse models
  • P53
  • P63
  • P73
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Dermatology
  • Molecular Biology
  • Biochemistry

Cite this

Crosstalk among p53 family members in cutaneous carcinoma. / Missero, Caterina; Antonini, Dario.

In: Experimental Dermatology, Vol. 23, No. 3, 2014, p. 143-146.

Research output: Contribution to journalArticle

Missero, Caterina ; Antonini, Dario. / Crosstalk among p53 family members in cutaneous carcinoma. In: Experimental Dermatology. 2014 ; Vol. 23, No. 3. pp. 143-146.
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