Crosstalk between angiogenesis and lymphangiogenesis in tumor progression

C. Scavelli, A. Vacca, G. Di Pietro, F. Dammacco, D. Ribatti

Research output: Contribution to journalArticle


Extensive studies have identified reliable markers of lymphatic endothelial cells, and mechanisms and molecules that regulate development and growth of the lymphatic vessels. Vascular endothelial growth factors (VEGF)-C and VEGF-D, and their cognate receptor tyrosine kinase, VEGF receptor-3 (VEGFR-3), are critical regulators of lymphangiogenesis. By binding to its endothelial cell surface receptors VEGFR-1 and VEGFR-2, VEGF-A mediates vascular leakage, endothelial proliferation and migration. Angiopoietin-2 (Ang-2) is expressed at sites of blood vessel remodeling and invasion, and factors that induce angiogenesis in vivo, such as VEGF-A, upregulate Ang-2 in endothelial cells. In this review, we summarize the literature concerning the crosstalk between angiogenesis and lymphangiogenesis in tumor progression, that is, involvement of VEGF-C, VEGF-D and VEGFR-3 in angiogenesis, and the role played by VEGF-A and Ang-2 in lymphangiogenesis, respectively.

Original languageEnglish
Pages (from-to)1054-1058
Number of pages5
Issue number6
Publication statusPublished - Jun 2004


  • Ang-2
  • Angiogenesis
  • Lymphangiogenesis
  • Tumor progression
  • VEG-A
  • VEGF-C
  • VEGF-D
  • VEGFR-3

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

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    Scavelli, C., Vacca, A., Di Pietro, G., Dammacco, F., & Ribatti, D. (2004). Crosstalk between angiogenesis and lymphangiogenesis in tumor progression. Leukemia, 18(6), 1054-1058.