Crosstalk Between Oxidative Stress and Mitochondrial Damage: Focus on Amyotrophic Lateral Sclerosis

Viviana Greco, Patrizia Longone, Alida Spalloni, Luisa Pieroni, Andrea Urbani

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Proteins oxidation by reactive species is implicated in the aetiology or progression of a panoply of disorders and diseases such as neurodegenerative disorders. It is becoming increasingly evident that redox imbalance in the brain mediates neurodegeneration. Free radicals, as reactive species of oxygen (ROS) but also reactive nitrogen species (RNS) and reactive sulfur species (RSS), are generated in vivo from several sources. Within the cell the mitochondria represent the main source of ROS and mitochondrial dysfunction is both the major contributor to oxidative stress (OS) as well its major consequence. To date there are no doubts that a condition of OS added to other factors as mitochondrial damage in mtDNA or mitochondrial respiratory chain, may contribute to trigger or amplify mechanisms leading to neurodegenerative disorders. In this chapter, we aim at illustrate the molecular interplay occurring between mitochondria and OS focusing on Amyotrophic Lateral Sclerosis, describing a phenotypic reprogramming mechanism of mitochondria in complex neurological disorder.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages71-82
Number of pages12
DOIs
Publication statusPublished - Jan 1 2019

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1158
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

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Keywords

  • ALS
  • Mitochondrial damage
  • Oxidative stress
  • Reactive species
  • Redox proteomics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Greco, V., Longone, P., Spalloni, A., Pieroni, L., & Urbani, A. (2019). Crosstalk Between Oxidative Stress and Mitochondrial Damage: Focus on Amyotrophic Lateral Sclerosis. In Advances in Experimental Medicine and Biology (pp. 71-82). (Advances in Experimental Medicine and Biology; Vol. 1158). Springer New York LLC. https://doi.org/10.1007/978-981-13-8367-0_5