Cruciferous vegetables and cancer risk in a network of case-control studies

C. Bosetti, M. Filomeno, P. Riso, J. Polesel, F. Levi, R. Talamini, M. Montella, E. Negri, S. Franceschi, C. La Vecchia

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Abstract

Background: Cruciferous vegetables have been suggested to protect against various cancers, though the issue is open to discussion. To further understand their role, we analyzed data from a network of case-control studies conducted in Italy and Switzerland. Patients and methods: The studies included a total of 1468 cancers of the oral cavity/pharynx, 505 of the esophagus, 230 of the stomach, 2390 of the colorectum, 185 of the liver, 326 of the pancreas, 852 of the larynx, 3034 of the breast, 367 of the endometrium, 1031 of the ovary, 1294 of the prostate, 767 of the kidney, and 11 492 controls. All cancers were incident, histologically confirmed; controls were subjects admitted to the same network of hospitals as cases for a wide spectrum of acute nonneoplastic conditions. Results: The multivariate odds ratio (OR) for consumption of cruciferous vegetables at least once a week as compared with no/occasional consumption was significantly reduced for cancer of the oral cavity/pharynx (OR = 0.83), esophagus (OR = 0.72), colorectum (OR = 0.83), breast (OR = 0.83), and kidney (OR = 0.68). The OR was below unity, but not significant, for stomach (OR = 0.90), liver (OR = 0.72), pancreatic (OR = 0.90), laryngeal (OR = 0.84), endometrial (OR = 0.93), ovarian (OR = 0.91), and prostate (OR = 0.87) cancer. Conclusion: This large series of studies provides additional evidence of a favorable effect of cruciferous vegetables on several common cancers.

Original languageEnglish
Article numbermdr604
Pages (from-to)2198-2203
Number of pages6
JournalAnnals of Oncology
Volume23
Issue number8
DOIs
Publication statusPublished - Aug 2012

Fingerprint

Vegetables
Case-Control Studies
Odds Ratio
Neoplasms
Mouth Neoplasms
Pharynx
Esophagus
Mouth
Prostate
Stomach
Breast
Kidney
Liver
Larynx
Endometrium
Switzerland
Italy
Pancreas
Ovary

Keywords

  • Brassicaceae
  • Cancer
  • Case-control study
  • Cruciferous vegetables
  • Risk factor
  • Vegetables

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Bosetti, C., Filomeno, M., Riso, P., Polesel, J., Levi, F., Talamini, R., ... La Vecchia, C. (2012). Cruciferous vegetables and cancer risk in a network of case-control studies. Annals of Oncology, 23(8), 2198-2203. [mdr604]. https://doi.org/10.1093/annonc/mdr604

Cruciferous vegetables and cancer risk in a network of case-control studies. / Bosetti, C.; Filomeno, M.; Riso, P.; Polesel, J.; Levi, F.; Talamini, R.; Montella, M.; Negri, E.; Franceschi, S.; La Vecchia, C.

In: Annals of Oncology, Vol. 23, No. 8, mdr604, 08.2012, p. 2198-2203.

Research output: Contribution to journalArticle

Bosetti, C, Filomeno, M, Riso, P, Polesel, J, Levi, F, Talamini, R, Montella, M, Negri, E, Franceschi, S & La Vecchia, C 2012, 'Cruciferous vegetables and cancer risk in a network of case-control studies', Annals of Oncology, vol. 23, no. 8, mdr604, pp. 2198-2203. https://doi.org/10.1093/annonc/mdr604
Bosetti, C. ; Filomeno, M. ; Riso, P. ; Polesel, J. ; Levi, F. ; Talamini, R. ; Montella, M. ; Negri, E. ; Franceschi, S. ; La Vecchia, C. / Cruciferous vegetables and cancer risk in a network of case-control studies. In: Annals of Oncology. 2012 ; Vol. 23, No. 8. pp. 2198-2203.
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abstract = "Background: Cruciferous vegetables have been suggested to protect against various cancers, though the issue is open to discussion. To further understand their role, we analyzed data from a network of case-control studies conducted in Italy and Switzerland. Patients and methods: The studies included a total of 1468 cancers of the oral cavity/pharynx, 505 of the esophagus, 230 of the stomach, 2390 of the colorectum, 185 of the liver, 326 of the pancreas, 852 of the larynx, 3034 of the breast, 367 of the endometrium, 1031 of the ovary, 1294 of the prostate, 767 of the kidney, and 11 492 controls. All cancers were incident, histologically confirmed; controls were subjects admitted to the same network of hospitals as cases for a wide spectrum of acute nonneoplastic conditions. Results: The multivariate odds ratio (OR) for consumption of cruciferous vegetables at least once a week as compared with no/occasional consumption was significantly reduced for cancer of the oral cavity/pharynx (OR = 0.83), esophagus (OR = 0.72), colorectum (OR = 0.83), breast (OR = 0.83), and kidney (OR = 0.68). The OR was below unity, but not significant, for stomach (OR = 0.90), liver (OR = 0.72), pancreatic (OR = 0.90), laryngeal (OR = 0.84), endometrial (OR = 0.93), ovarian (OR = 0.91), and prostate (OR = 0.87) cancer. Conclusion: This large series of studies provides additional evidence of a favorable effect of cruciferous vegetables on several common cancers.",
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AU - Filomeno, M.

AU - Riso, P.

AU - Polesel, J.

AU - Levi, F.

AU - Talamini, R.

AU - Montella, M.

AU - Negri, E.

AU - Franceschi, S.

AU - La Vecchia, C.

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N2 - Background: Cruciferous vegetables have been suggested to protect against various cancers, though the issue is open to discussion. To further understand their role, we analyzed data from a network of case-control studies conducted in Italy and Switzerland. Patients and methods: The studies included a total of 1468 cancers of the oral cavity/pharynx, 505 of the esophagus, 230 of the stomach, 2390 of the colorectum, 185 of the liver, 326 of the pancreas, 852 of the larynx, 3034 of the breast, 367 of the endometrium, 1031 of the ovary, 1294 of the prostate, 767 of the kidney, and 11 492 controls. All cancers were incident, histologically confirmed; controls were subjects admitted to the same network of hospitals as cases for a wide spectrum of acute nonneoplastic conditions. Results: The multivariate odds ratio (OR) for consumption of cruciferous vegetables at least once a week as compared with no/occasional consumption was significantly reduced for cancer of the oral cavity/pharynx (OR = 0.83), esophagus (OR = 0.72), colorectum (OR = 0.83), breast (OR = 0.83), and kidney (OR = 0.68). The OR was below unity, but not significant, for stomach (OR = 0.90), liver (OR = 0.72), pancreatic (OR = 0.90), laryngeal (OR = 0.84), endometrial (OR = 0.93), ovarian (OR = 0.91), and prostate (OR = 0.87) cancer. Conclusion: This large series of studies provides additional evidence of a favorable effect of cruciferous vegetables on several common cancers.

AB - Background: Cruciferous vegetables have been suggested to protect against various cancers, though the issue is open to discussion. To further understand their role, we analyzed data from a network of case-control studies conducted in Italy and Switzerland. Patients and methods: The studies included a total of 1468 cancers of the oral cavity/pharynx, 505 of the esophagus, 230 of the stomach, 2390 of the colorectum, 185 of the liver, 326 of the pancreas, 852 of the larynx, 3034 of the breast, 367 of the endometrium, 1031 of the ovary, 1294 of the prostate, 767 of the kidney, and 11 492 controls. All cancers were incident, histologically confirmed; controls were subjects admitted to the same network of hospitals as cases for a wide spectrum of acute nonneoplastic conditions. Results: The multivariate odds ratio (OR) for consumption of cruciferous vegetables at least once a week as compared with no/occasional consumption was significantly reduced for cancer of the oral cavity/pharynx (OR = 0.83), esophagus (OR = 0.72), colorectum (OR = 0.83), breast (OR = 0.83), and kidney (OR = 0.68). The OR was below unity, but not significant, for stomach (OR = 0.90), liver (OR = 0.72), pancreatic (OR = 0.90), laryngeal (OR = 0.84), endometrial (OR = 0.93), ovarian (OR = 0.91), and prostate (OR = 0.87) cancer. Conclusion: This large series of studies provides additional evidence of a favorable effect of cruciferous vegetables on several common cancers.

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KW - Risk factor

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