Cryoablation of typical AVNRT: Younger age and administration of bonus ablation favor long-term success

Paolo Pieragnoli, Alessandro Paoletti Perini, Luca Checchi, Gianmarco Carrassa, Andrea Giomi, Paolo Carrai, Antonio Michelucci, Luigi Padeletti, Giuseppe Ricciardi

Research output: Contribution to journalArticlepeer-review


Background Cryoablation (CA) is an emerging tool for the treatment of supraventricular tachyarrhythmias. Determinants of long-term success still need clarification. Objective The purpose of this study was to assess which patients' and procedural features affect the long-term efficacy of CA for typical atrioventricular nodal reentrant tachycardia (AVNRT). Methods Eighty-five consecutive patients undergoing CA for typical AVNRT were divided into 3 groups of age: group A, ≤20 years, n = 20 (23.5%); group B, 21-50 years, n = 30 (35.3%); group C, ≥51 years, n = 35 (41.2%). CA was performed for 5 minutes at -75°C in all; 4-minute bonus CA was delivered if not contraindicated (ie, transient PR interval lengthening during the first application and narrow triangle of Koch). The efficacy end point was the absence of recurrences at 12-month follow-up. Results CA was acutely successful in all 85 patients (100%). Bonus ablation was performed in 69 (81.2%). No permanent complications were observed. At follow-up, AVNRT recurrences occurred in 9 patients (10.6%): group A, 0 (0%); group B, 2 (6.7%), group C, 7 (20%). Incidence of recurrences was significantly different between age groups (P =.047) and between patients receiving (7.2%) and not receiving (25.0%) bonus CA (P =.038). In multivariable analysis, age groups (odds ratio [OR] 5.917; 95% confidence interval [CI] 1.372-25.518; P =.017) and bonus CA (OR 0.115; 95% CI 0.018-0.724; P =.021) were the only independent predictors of recurrences. Furthermore, age as a continuous variable remained statistically associated with recurrences (OR 1.046; 95% CI 1.002-1.091; P =.038). Conclusion CA is effective and safe for typical AVNRT ablation. Younger age and bonus CA administration are independent predictors of success at 12 months. Incidence of recurrences is low in patients younger than 21 years.

Original languageEnglish
Article number6298
Pages (from-to)2125-2131
Number of pages7
JournalHeart Rhythm
Issue number10
Publication statusPublished - Oct 1 2015


  • Ablation
  • Age
  • Arrhythmias
  • Atrioventricular nodal reentrant tachycardia
  • Cryoablation
  • Cryotherapy
  • Recurrences

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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