Vasculite leucocitoclasica crioglobulinemica ed epatite C

Translated title of the contribution: Cryoglobulinemic leukocytoclastic vasculitis and hepatitis C virus infection

V. Di Lernia, G. Albertini, G. Bisighini

Research output: Contribution to journalArticle

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Abstract

The authors report a case of cutaneous vasculitis in a 59-year-old schizophrenic male. Clinical manifestations were characterized by recurrent bouts of purpuric macules and papules on both legs, extending to the thighs. Histologic examination showed a leukocytoclastic vasculitis. Biochemical investigations showed cryoglobulinemia and anti hepatitis C virus antibodies in his serum. Hepatitis C virus RNA was found by PCR. No therapy was given. Clinical manifestations regressed but the patient experienced recurrences triggered by standing. Epidemiologic and molecular investigations suggest a cause-effect relationship between hepatitis C virus and mixed cryoglobulinemia, which, in turn, can cause a cutaneous or systemic vasculitis by the deposition of immune complexes in post-capillary venules. In HCV-patients mixed cryoglobulinemia shows rheumatoid factor activity. For these reasons, in these patients rheumatoid factor is considered a useful, sensitive marker for mixed cryoglobulinemia when these serum immunoglobulins are not detectable. Cutaneous vasculitis is a skin disease possibly correlated to hepatitis C virus infection. Because it can be a presenting feature of HCV infection, the search for cryoglobulin and anti hepatitis C virus antibodies has to be performed in every case of cutaneous vasculitis.

Original languageItalian
Pages (from-to)203-205
Number of pages3
JournalGiornale Italiano di Dermatologia e Venereologia
Volume132
Issue number3
Publication statusPublished - 1997

Fingerprint

Cryoglobulinemia
Virus Diseases
Hepacivirus
Vasculitis
Skin
Hepatitis C Antibodies
Rheumatoid Factor
Cryoglobulins
Systemic Vasculitis
Venules
Thigh
Antigen-Antibody Complex
Serum
Skin Diseases
Immunoglobulins
Leg
RNA
Recurrence
Polymerase Chain Reaction
Erythema elevatum diutinum

ASJC Scopus subject areas

  • Dermatology

Cite this

Vasculite leucocitoclasica crioglobulinemica ed epatite C. / Di Lernia, V.; Albertini, G.; Bisighini, G.

In: Giornale Italiano di Dermatologia e Venereologia, Vol. 132, No. 3, 1997, p. 203-205.

Research output: Contribution to journalArticle

Di Lernia, V. ; Albertini, G. ; Bisighini, G. / Vasculite leucocitoclasica crioglobulinemica ed epatite C. In: Giornale Italiano di Dermatologia e Venereologia. 1997 ; Vol. 132, No. 3. pp. 203-205.
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