Vasculite leucocitoclasica crioglobulinemica ed epatite C

Translated title of the contribution: Cryoglobulinemic leukocytoclastic vasculitis and hepatitis C virus infection

V. Di Lernia, G. Albertini, G. Bisighini

Research output: Contribution to journalArticlepeer-review


The authors report a case of cutaneous vasculitis in a 59-year-old schizophrenic male. Clinical manifestations were characterized by recurrent bouts of purpuric macules and papules on both legs, extending to the thighs. Histologic examination showed a leukocytoclastic vasculitis. Biochemical investigations showed cryoglobulinemia and anti hepatitis C virus antibodies in his serum. Hepatitis C virus RNA was found by PCR. No therapy was given. Clinical manifestations regressed but the patient experienced recurrences triggered by standing. Epidemiologic and molecular investigations suggest a cause-effect relationship between hepatitis C virus and mixed cryoglobulinemia, which, in turn, can cause a cutaneous or systemic vasculitis by the deposition of immune complexes in post-capillary venules. In HCV-patients mixed cryoglobulinemia shows rheumatoid factor activity. For these reasons, in these patients rheumatoid factor is considered a useful, sensitive marker for mixed cryoglobulinemia when these serum immunoglobulins are not detectable. Cutaneous vasculitis is a skin disease possibly correlated to hepatitis C virus infection. Because it can be a presenting feature of HCV infection, the search for cryoglobulin and anti hepatitis C virus antibodies has to be performed in every case of cutaneous vasculitis.

Translated title of the contributionCryoglobulinemic leukocytoclastic vasculitis and hepatitis C virus infection
Original languageItalian
Pages (from-to)203-205
Number of pages3
JournalGiornale Italiano di Dermatologia e Venereologia
Issue number3
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Dermatology


Dive into the research topics of 'Cryoglobulinemic leukocytoclastic vasculitis and hepatitis C virus infection'. Together they form a unique fingerprint.

Cite this