Cryptic subtelomeric translocation t(2;16)(q37;q24) segregating in a family with unexplained stillbirths and a dysmorphic, slightly retarded child

Daniela Giardino, Palma Finelli, Giulietta Gottardi, Donata Clerici, Fabio Mosca, Vincenza Briscioli, Lidia Larizza

Research output: Contribution to journalArticlepeer-review

Abstract

We here describe a submicroscopic translocation affecting the subtelomeric regions of chromosomes 2q and 16q, and segregating in a family with stillbirths, early pregnancy losses, and two dysmorphic and slightly retarded babies. FISH analysis showed a 46,XY,der(2)t(2;16) (q37.3;q24.3) in the propositus, and a balanced t(2;16) in his mother, her conceptus and maternal grandfather. FISH with YACs and BACs made it possible to map the 2q37 breakpoint precisely between the regions covered by y952E1 and y746H1, and the 16q breakpoint between the regions encompassed by bA 309g16 and bA 533d19. The contribution of 2q37.3 monosomy and 16q24.3 trisomy to the proband's phenotype is compared with that in reported patients with similar imbalances of either chromosome.

Original languageEnglish
Pages (from-to)881-886
Number of pages6
JournalEuropean Journal of Human Genetics
Volume9
Issue number12
DOIs
Publication statusPublished - 2001

Keywords

  • 16q partial trisomy
  • 2qter deletion
  • Prenatal diagnosis
  • Psychomotor retardation
  • Subtelomeric translocation

ASJC Scopus subject areas

  • Genetics(clinical)

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