Cryptococcus neoformans fatal sepsis in a chronic lymphocytic leukemia patient treated with alemtuzumab: case report and review of the literature

M. Bassetti, E. Repettox, M. Mikulska, M. Miglino, M. Clavio, [No Value] Gobbi.M., E. Righi, C. Viscoli

Research output: Contribution to journalArticle

Abstract

Cryptococcosis is a disseminated fungal disease typically associated with immunosuppression and characterized by high mortality rates. Cryptococcus neoformans has been reported to be isolated from blood cultures in around 20% of patients with cryptococcosis, and cryptococcemia has been correlated with poor prognosis. We report a case of fatal C. neoformans fungemia in a neutropenic patient with a history of chronic lymphocytic leukemia treated with alemtuzumab. The patient presented with loss of consciousness and died after 5 days of antifungal therapy with liposomal amphotericin B. The international literature regarding opportunistic infections after immunosuppressive therapy with alemtuzumab with particular attention on fun- gal infections has also been reviewed.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalJournal of Chemotherapy
Volume21
Issue number2
Publication statusPublished - Apr 2009

Keywords

  • Alemtuzumab
  • Chronic lymphocytic leukemia
  • Cryptococcosis
  • Liposomal amphothericin B

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Oncology
  • Pharmacology

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