Abstract
Cryptosporidial infection in AIDS patients has a high mortality rate. This fact may be related to the absence of an effective therapy. In this report we want to study the clinical evolution of this opportunistic infection in AIDS patients, treated with different drugs. We have reviewed clinical records of 12 patients, HIV seropositive, with cryptosporidial infection. Early symptoms were loss of weight and diarrhoea, with an altered hydroelectrolytic balance. Stools examination allowed us to identify cryptosporidial oocysts (modified Ziehl-Neelsen stain, 100X). About therapy, we used, in different cycles and associations, spyramicin, erytromicin and clarithromicin, roxitromicin, α-DFMO and an analogous of somatostatin (octreotide). We obtained clinical and microbiological resolution in the patient treated with α-DFMO and, later, with octreotide, whereas the other patients presented poor clinical conditions. In these subjects we could not obtain the disappearance of Cryptosporidium spp. in the stools. Octreotide has demonstrated a fairly good efficacy. Our study confirms that no drugs can completely eradicate this pathogen.
| Original language | Italian |
|---|---|
| Pages (from-to) | 472-476 |
| Number of pages | 5 |
| Journal | Giornale di Malattie Infettive e Parassitarie |
| Volume | 44 |
| Issue number | 6 |
| Publication status | Published - 1992 |
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ASJC Scopus subject areas
- Parasitology
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CRIPTOSPORIDIOSI IN PAZIENTI HIV-POSITIVI : VALUTAZIONE TERAPEUTICA DI 12 CASI. / Tornari, P. M G; Carretto, E.; Sacchi, P.; Patruno, S. F A; Malfitano, A.; Scaglia, M.
In: Giornale di Malattie Infettive e Parassitarie, Vol. 44, No. 6, 1992, p. 472-476.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CRIPTOSPORIDIOSI IN PAZIENTI HIV-POSITIVI
T2 - VALUTAZIONE TERAPEUTICA DI 12 CASI
AU - Tornari, P. M G
AU - Carretto, E.
AU - Sacchi, P.
AU - Patruno, S. F A
AU - Malfitano, A.
AU - Scaglia, M.
PY - 1992
Y1 - 1992
N2 - Cryptosporidial infection in AIDS patients has a high mortality rate. This fact may be related to the absence of an effective therapy. In this report we want to study the clinical evolution of this opportunistic infection in AIDS patients, treated with different drugs. We have reviewed clinical records of 12 patients, HIV seropositive, with cryptosporidial infection. Early symptoms were loss of weight and diarrhoea, with an altered hydroelectrolytic balance. Stools examination allowed us to identify cryptosporidial oocysts (modified Ziehl-Neelsen stain, 100X). About therapy, we used, in different cycles and associations, spyramicin, erytromicin and clarithromicin, roxitromicin, α-DFMO and an analogous of somatostatin (octreotide). We obtained clinical and microbiological resolution in the patient treated with α-DFMO and, later, with octreotide, whereas the other patients presented poor clinical conditions. In these subjects we could not obtain the disappearance of Cryptosporidium spp. in the stools. Octreotide has demonstrated a fairly good efficacy. Our study confirms that no drugs can completely eradicate this pathogen.
AB - Cryptosporidial infection in AIDS patients has a high mortality rate. This fact may be related to the absence of an effective therapy. In this report we want to study the clinical evolution of this opportunistic infection in AIDS patients, treated with different drugs. We have reviewed clinical records of 12 patients, HIV seropositive, with cryptosporidial infection. Early symptoms were loss of weight and diarrhoea, with an altered hydroelectrolytic balance. Stools examination allowed us to identify cryptosporidial oocysts (modified Ziehl-Neelsen stain, 100X). About therapy, we used, in different cycles and associations, spyramicin, erytromicin and clarithromicin, roxitromicin, α-DFMO and an analogous of somatostatin (octreotide). We obtained clinical and microbiological resolution in the patient treated with α-DFMO and, later, with octreotide, whereas the other patients presented poor clinical conditions. In these subjects we could not obtain the disappearance of Cryptosporidium spp. in the stools. Octreotide has demonstrated a fairly good efficacy. Our study confirms that no drugs can completely eradicate this pathogen.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026545796&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:0026545796
VL - 44
SP - 472
EP - 476
JO - Giornale di Malattie Infettive e Parassitarie
JF - Giornale di Malattie Infettive e Parassitarie
SN - 0017-0321
IS - 6
ER -