Crystalline calcium alendronate obtained by octacalcium phosphate digestion: A new chance for local treatment of bone loss diseases?

Elisa Boanini, Paola Torricelli, Massimo Gazzano, Milena Fini, Adriana Bigi

Research output: Contribution to journalArticle

Abstract

Octacalcium phosphate (OCP) interaction with alendronate (AL) solution results in the complete digestion of OCP: calcium ion is recruited by the bisphosphonate to yield quantitative precipitation of crystalline calcium alendronate monohydrate. This compound improves osteoblast differentiation and inhibits osteoclast proliferation and activity, both alone and, even more, in combination with OCP.

Original languageEnglish
Pages (from-to)4605-4611
Number of pages7
JournalAdvanced Materials
Volume25
Issue number33
DOIs
Publication statusPublished - Sep 6 2013

Keywords

  • bisphosphonate
  • in vitro co-cultures
  • octacalcium phosphate

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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