Crystallization and preliminary crystallographic data for the augmenter of liver regeneration

John P. Rose, Chia Kuei Wu, Antonio Francavilla, John G. Prelich, Angelo Iacobellis, Michio Hagiya, Abdul S. Rao, Thomas E. Starzl, Bi Cheng Wang

Research output: Contribution to journalArticlepeer-review

Abstract

A new cellular growth factor termed augmenter of liver regeneration (ALR) has been crystallized. ALR has been shown to have a proliferative effect on liver cells while at the same time producing an immunosuppressive effect on liver-resident natural killer cells and liver-resident mononuclear leukocytes. In addition, ALR appears to play an important role in the synthesis and stabilization of mitochondrial gene transcripts inactively regenerating cells. ALR crystals diffract to beyond 2 Å resolution and belong to space group P21212, with a = 125.1, b = 108.1 and c = 38.5 Å. Based on four molecules per asymmetric unit, the Matthews coefficient is calculated to be 2.16 Å3 Da-1 which corresponds to a solvent content of 43%.

Original languageEnglish
Pages (from-to)331-334
Number of pages4
JournalActa Crystallographica Section D: Biological Crystallography
Volume53
Issue number3
DOIs
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'Crystallization and preliminary crystallographic data for the augmenter of liver regeneration'. Together they form a unique fingerprint.

Cite this