Abstract
Objective To assess the connection between amyloid pathology and white matter (WM) macrostructural and microstructural damage in demented patients compared with controls. Methods Eighty-five participants were recruited: 65 with newly diagnosed Alzheimer's disease (AD), non-AD dementia or mild cognitive impairment and 20 age-matched and sex-matched healthy controls. β-amyloid 1-42 (Aβ) levels were determined in cerebrospinal fluid (CSF) samples from all patients and five controls. Among patients, 42 had pathological CSF Aβ levels (Aβ(+)), while 23 had normal CSF Aβ levels (Aβ(â ')). All participants underwent neurological examination, neuropsychological testing and brain MRI. We used T2-weighted scans to quantify WM lesion loads (LLs) and diffusion-weighted images to assess their microstructural substrate. Non-parametric statistical tests were used for between-group comparisons and multiple regression analyses. Results We found an increased WM-LL in Aβ(+) compared with both, healthy controls (p=0.003) and Aβ(â ') patients (p=0.02). Interestingly, CSF Aβ concentration was the best predictor of patients' WM-LL (r=â '0.30, p<0.05) when using age as a covariate. Lesion apparent diffusion coefficient value was higher in all patients than in controls (p=0.0001) and correlated with WM-LL (r=0.41, p=0.001). In Aβ(+), WM-LL correlated with WM microstructural damage in the left peritrigonal WM (p<0.0001). Conclusions WM damage is crucial in AD pathogenesis. The correlation between CSF Aβ levels and WM-LL suggests a direct link between amyloid pathology and WM macrostructural and microstructural damage.
| Original language | English |
|---|---|
| Pages (from-to) | 352-357 |
| Number of pages | 6 |
| Journal | Journal of Neurology, Neurosurgery and Psychiatry |
| Volume | 89 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 1 2018 |
Fingerprint
Keywords
- dementia
- multiple sclerosis
- myelin
- neroimmunology
- neuroradiology
ASJC Scopus subject areas
- Surgery
- Clinical Neurology
- Psychiatry and Mental health
Cite this
CSF β-amyloid and white matter damage : A new perspective on Alzheimer's disease. / Pietroboni, Anna M.; Scarioni, Marta; Carandini, Tiziana; Basilico, Paola; Cadioli, Marcello; Giulietti, Giovanni; Arighi, Andrea; Caprioli, Michela; Serra, Laura; Sina, Clara; Fenoglio, Chiara; Ghezzi, Laura; Fumagalli, Giorgio G.; De Riz, Milena A.; Calvi, Alberto; Triulzi, Fabio; Bozzali, Marco; Scarpini, Elio; Galimberti, Daniela.
In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 89, No. 4, 01.04.2018, p. 352-357.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CSF β-amyloid and white matter damage
T2 - A new perspective on Alzheimer's disease
AU - Pietroboni, Anna M.
AU - Scarioni, Marta
AU - Carandini, Tiziana
AU - Basilico, Paola
AU - Cadioli, Marcello
AU - Giulietti, Giovanni
AU - Arighi, Andrea
AU - Caprioli, Michela
AU - Serra, Laura
AU - Sina, Clara
AU - Fenoglio, Chiara
AU - Ghezzi, Laura
AU - Fumagalli, Giorgio G.
AU - De Riz, Milena A.
AU - Calvi, Alberto
AU - Triulzi, Fabio
AU - Bozzali, Marco
AU - Scarpini, Elio
AU - Galimberti, Daniela
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Objective To assess the connection between amyloid pathology and white matter (WM) macrostructural and microstructural damage in demented patients compared with controls. Methods Eighty-five participants were recruited: 65 with newly diagnosed Alzheimer's disease (AD), non-AD dementia or mild cognitive impairment and 20 age-matched and sex-matched healthy controls. β-amyloid 1-42 (Aβ) levels were determined in cerebrospinal fluid (CSF) samples from all patients and five controls. Among patients, 42 had pathological CSF Aβ levels (Aβ(+)), while 23 had normal CSF Aβ levels (Aβ(â ')). All participants underwent neurological examination, neuropsychological testing and brain MRI. We used T2-weighted scans to quantify WM lesion loads (LLs) and diffusion-weighted images to assess their microstructural substrate. Non-parametric statistical tests were used for between-group comparisons and multiple regression analyses. Results We found an increased WM-LL in Aβ(+) compared with both, healthy controls (p=0.003) and Aβ(â ') patients (p=0.02). Interestingly, CSF Aβ concentration was the best predictor of patients' WM-LL (r=â '0.30, p<0.05) when using age as a covariate. Lesion apparent diffusion coefficient value was higher in all patients than in controls (p=0.0001) and correlated with WM-LL (r=0.41, p=0.001). In Aβ(+), WM-LL correlated with WM microstructural damage in the left peritrigonal WM (p<0.0001). Conclusions WM damage is crucial in AD pathogenesis. The correlation between CSF Aβ levels and WM-LL suggests a direct link between amyloid pathology and WM macrostructural and microstructural damage.
AB - Objective To assess the connection between amyloid pathology and white matter (WM) macrostructural and microstructural damage in demented patients compared with controls. Methods Eighty-five participants were recruited: 65 with newly diagnosed Alzheimer's disease (AD), non-AD dementia or mild cognitive impairment and 20 age-matched and sex-matched healthy controls. β-amyloid 1-42 (Aβ) levels were determined in cerebrospinal fluid (CSF) samples from all patients and five controls. Among patients, 42 had pathological CSF Aβ levels (Aβ(+)), while 23 had normal CSF Aβ levels (Aβ(â ')). All participants underwent neurological examination, neuropsychological testing and brain MRI. We used T2-weighted scans to quantify WM lesion loads (LLs) and diffusion-weighted images to assess their microstructural substrate. Non-parametric statistical tests were used for between-group comparisons and multiple regression analyses. Results We found an increased WM-LL in Aβ(+) compared with both, healthy controls (p=0.003) and Aβ(â ') patients (p=0.02). Interestingly, CSF Aβ concentration was the best predictor of patients' WM-LL (r=â '0.30, p<0.05) when using age as a covariate. Lesion apparent diffusion coefficient value was higher in all patients than in controls (p=0.0001) and correlated with WM-LL (r=0.41, p=0.001). In Aβ(+), WM-LL correlated with WM microstructural damage in the left peritrigonal WM (p<0.0001). Conclusions WM damage is crucial in AD pathogenesis. The correlation between CSF Aβ levels and WM-LL suggests a direct link between amyloid pathology and WM macrostructural and microstructural damage.
KW - dementia
KW - multiple sclerosis
KW - myelin
KW - neroimmunology
KW - neuroradiology
UR - http://www.scopus.com/inward/record.url?scp=85042425857&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042425857&partnerID=8YFLogxK
U2 - 10.1136/jnnp-2017-316603
DO - 10.1136/jnnp-2017-316603
M3 - Article
AN - SCOPUS:85042425857
VL - 89
SP - 352
EP - 357
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
SN - 0022-3050
IS - 4
ER -