CSF β-EP in headache and depression

G. Nappi, F. Facchinetti, E. Martignoni, F. Petraglia, G. Bono, A. R. Genazzani

Research output: Contribution to journalArticlepeer-review


Cerebrospinal fluid (CSF) levels of β-endorphin (β-EP) were measured in 9 migraineurs with interparoxysmal headache (MIH), in 13 patients with major depression in an active phase (5 suffered from MIH), and in 16 age-matched controls. β-EP was measured by specific RIA after gel-chromatography. While β-EP levels of depressed patients (58.5 ± 21.0 fmol/ml, M ± SD) were similar to those of controls (65.8 ± 26.6), those of migraineurs (15.0 ± 11.1) were significantly reduced (p

Original languageEnglish
Pages (from-to)99-101
Number of pages3
Issue number2
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Clinical Neurology


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