CSF dynamics and brain volume in multiple sclerosis are associated with extracranial venous flow anomalies: A pilot study

P. Zamboni, E. Menegatti, B. Weinstock-Guttman, C. Schirda, J. L. Cox, A. M. Malagoni, D. Hojnacki, C. Kennedy, E. Carl, M. G. Dwyer, N. Bergsland, R. Galeotti, S. Hussein, I. Bartolomei, F. Salvi, M. Ramanathan, R. Zivadinov

Research output: Contribution to journalArticle

Abstract

Aim. We previously reported unexpectedly robust associations between vascular haemodynamic (VH) anomalies in the principal extracranial cerebral veins, causing chronic cerebrospinal venous insufficiency (CCSVI), and multiple sclerosis (MS). Aim of this study was to investigate the relationship between the VH changes and MRI measures of MS disease severity in a cross sectional survey. Methods. The number of anomalous VH criteria were measured using an echo-color Doppler, whereas CSF flow, atrophy and lesion measures were obtained from quantitative magnetic resonance imaging (MRI) analysis in sixteen consecutive relapsing-remirting MS patients, (mean age: 36.1±SD 7.3 years, disease duration: 7.5±1.9 years and median EDSS: 2.5) and in 8 healthy controls (HC) with similar age and sex distributions. Results. All 16 MS patients investigated and none of the HCs met the VH criteria for CCSVI (P

Original languageEnglish
Pages (from-to)140-148
Number of pages9
JournalInternational Angiology
Volume29
Issue number2
Publication statusPublished - Apr 2010

Keywords

  • Cerebrospinal fluid
  • Magnetic resonance imaging
  • Multiple sclerosis
  • Ultrasonography, Doppler, color
  • Venous insufficiency

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Zamboni, P., Menegatti, E., Weinstock-Guttman, B., Schirda, C., Cox, J. L., Malagoni, A. M., Hojnacki, D., Kennedy, C., Carl, E., Dwyer, M. G., Bergsland, N., Galeotti, R., Hussein, S., Bartolomei, I., Salvi, F., Ramanathan, M., & Zivadinov, R. (2010). CSF dynamics and brain volume in multiple sclerosis are associated with extracranial venous flow anomalies: A pilot study. International Angiology, 29(2), 140-148.