CSF from MS patients can induce acute conduction block in the isolated optic nerve

Diego Centonze, S. Rossi, L. Boffa, V. Versace, M. G. Palmieri, M. D. Caramia, G. Bernardi

Research output: Contribution to journalArticle

Abstract

In the present in vitro electrophysiological study, the acute effects of the cerebrospinal fluid (CSF) from multiple sclerosis (MS) and control subjects were measured on the axonal conduction of rat optic nerve, a central tract that is commonly affected in MS. Optic nerve compound action potential (CAP) amplitude was insensitive to the application of CSF obtained from the whole population of non-MS patients and from seven of 15 MS CSF. In the remaining eight MS cases, conversely, a time-dependent depression of CAP amplitude was observed. The reversible blockade of ion channels by soluble substances might account, at least in part, for the transient symptoms often seen in MS patients.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalEuropean Journal of Neurology
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 2005

Keywords

  • CAP
  • Demyelination
  • in vitro electrophysiology
  • Nerve conduction
  • QYNAD
  • Sodium channels

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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