CSF lactate levels, τ proteins, cognitive decline: A dynamic relationship in Alzheimer's disease

C. Liguori, A. Stefani, G. Sancesario, G. M. Sancesario, M. G. Marciani, M. Pierantozzi

Research output: Contribution to journalArticle

Abstract

Objectives: To investigate, in patients with Alzheimer's Disease (AD), the possible interplay linking alteration of neuronal energy metabolism, as measured via cerebrospinal fluid (CSF) lactate concentration, to severity of AD neurodegenerative processes and impairment of cognitive abilities. Methods: In this study we measured and correlated CSF lactate concentrations, AD biomarker levels (τ-proteins and β-amyloid) and Mini-Mental State Examination (MMSE) score in a population of drug-naive patients with AD ranging from mild (MMSE≥21/30) to moderate-severe (MMSE

Original languageEnglish
Pages (from-to)655-659
Number of pages5
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume86
Issue number6
DOIs
Publication statusPublished - Jun 1 2015

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery
  • Arts and Humanities (miscellaneous)

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    Liguori, C., Stefani, A., Sancesario, G., Sancesario, G. M., Marciani, M. G., & Pierantozzi, M. (2015). CSF lactate levels, τ proteins, cognitive decline: A dynamic relationship in Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 86(6), 655-659. https://doi.org/10.1136/jnnp-2014-308577