CSF lactate levels, τ proteins, cognitive decline

A dynamic relationship in Alzheimer's disease

C. Liguori, A. Stefani, G. Sancesario, G. M. Sancesario, M. G. Marciani, M. Pierantozzi

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Objectives: To investigate, in patients with Alzheimer's Disease (AD), the possible interplay linking alteration of neuronal energy metabolism, as measured via cerebrospinal fluid (CSF) lactate concentration, to severity of AD neurodegenerative processes and impairment of cognitive abilities. Methods: In this study we measured and correlated CSF lactate concentrations, AD biomarker levels (τ-proteins and β-amyloid) and Mini-Mental State Examination (MMSE) score in a population of drug-naive patients with AD ranging from mild (MMSE≥21/30) to moderate-severe (MMSE

Original languageEnglish
Pages (from-to)655-659
Number of pages5
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume86
Issue number6
DOIs
Publication statusPublished - Jun 1 2015

Fingerprint

Cerebrospinal Fluid
Lactic Acid
Alzheimer Disease
Proteins
Amyloidogenic Proteins
Aptitude
Energy Metabolism
Biomarkers
Cognitive Dysfunction
Protein
Alzheimer's Disease
Pharmaceutical Preparations
Population
Mental State

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery
  • Arts and Humanities (miscellaneous)

Cite this

Liguori, C., Stefani, A., Sancesario, G., Sancesario, G. M., Marciani, M. G., & Pierantozzi, M. (2015). CSF lactate levels, τ proteins, cognitive decline: A dynamic relationship in Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 86(6), 655-659. https://doi.org/10.1136/jnnp-2014-308577

CSF lactate levels, τ proteins, cognitive decline : A dynamic relationship in Alzheimer's disease. / Liguori, C.; Stefani, A.; Sancesario, G.; Sancesario, G. M.; Marciani, M. G.; Pierantozzi, M.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 86, No. 6, 01.06.2015, p. 655-659.

Research output: Contribution to journalArticle

Liguori, C, Stefani, A, Sancesario, G, Sancesario, GM, Marciani, MG & Pierantozzi, M 2015, 'CSF lactate levels, τ proteins, cognitive decline: A dynamic relationship in Alzheimer's disease', Journal of Neurology, Neurosurgery and Psychiatry, vol. 86, no. 6, pp. 655-659. https://doi.org/10.1136/jnnp-2014-308577
Liguori, C. ; Stefani, A. ; Sancesario, G. ; Sancesario, G. M. ; Marciani, M. G. ; Pierantozzi, M. / CSF lactate levels, τ proteins, cognitive decline : A dynamic relationship in Alzheimer's disease. In: Journal of Neurology, Neurosurgery and Psychiatry. 2015 ; Vol. 86, No. 6. pp. 655-659.
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