CSF neurofilament protein (NFL) - A marker of active HIV-related neurodegeneration

Sahra Abdulle, Åsa Mellgren, Bruce J. Brew, Paola Cinque, Lars Hagberg, Richard W. Price, Lars Rosengren, Magnus Gisslén

Research output: Contribution to journalArticle

Abstract

Background and methods: The light subunit of the neurofilament protein (NFL), a major structural component of myelinated axons, is a sensitive indicator of axonal injury in the central nervous system (CNS) in a variety of neurodegenerative disorders. Cerebrospinal fluid (CSF) NFL concentrations were measured by ELISA (normal <250 ng/l) in archived samples from 210 HIV-infected patients not taking antiretroviral treatment: 55 with AIDS dementia complex (ADC), 44 with various CNS opportunistic infections/tumours (CNS OIs), 95 without neurological symptoms or signs, and 16 with primary HIV infection (PHI). The effect of highly active antiretroviral treatment (HAART) was studied by repeated CSF sampling in four of the ADC patients initiating treatment. Results: CSF NFL concentrations were significantly higher in patients with ADC (median 2590 ng/l, IQR 780-7360) and CNS OIs (2315 ng/l, 985-7390 ng/l) than in neuroasymptomatic patients (

Original languageEnglish
Pages (from-to)1026-1032
Number of pages7
JournalJournal of Neurology
Volume254
Issue number8
DOIs
Publication statusPublished - Aug 2007

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Keywords

  • AIDS dementia complex
  • Cerebrospinal fluid
  • HIV
  • Neurofilament protein

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Abdulle, S., Mellgren, Å., Brew, B. J., Cinque, P., Hagberg, L., Price, R. W., Rosengren, L., & Gisslén, M. (2007). CSF neurofilament protein (NFL) - A marker of active HIV-related neurodegeneration. Journal of Neurology, 254(8), 1026-1032. https://doi.org/10.1007/s00415-006-0481-8