CSF oligoclonal banding pattern changes in a long-surviving SSPE patient treated with α-IFN

L. M E Grimaldi, G. V. Martino

Research output: Contribution to journalArticle

Abstract

Oligoclonal bands are a constant, non-modifiable feature of CSF examination in SSPE. We studied CSF oligoclonal IgG banding pattern in a long-surviving SSPE patient treated with serial courses of intrathecal α-IFN. α-IFN administration did not significantly modify the clinical status of the patient. Oligoclonal IgG banding pattern varied during the 58 month-long treatment. Oligoclonal bands disappeared at the end of the first course only to reappear during the third course, 2 years later, with a different electrophoretic pattern. We conclude that oligoclonal bands may transiently disappear from the CSF of long-surviving SSPE patients. Although α-IFN treatment induces no clinical improvement, it might affect the quality of Ig production.

Original languageEnglish
Pages (from-to)187-191
Number of pages5
JournalItalian Journal of Neurological Sciences
Volume12
Issue number2
DOIs
Publication statusPublished - Apr 1991

Keywords

  • α-IFN
  • oligoclonal bands
  • SSPE

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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