Abstract
Background: A periventricular gradient of normal appearing white matter (NAWM) damage has been described in multiple sclerosis (MS), including subjects with clinically isolated syndrome (CIS). The pathological mechanisms underlying this gradient is not currently understood. Methods: 34 CIS subjects were enrolled and underwent cerebrospinal fluid oligo-clonal bands (CSF-OCB) evaluation. Moreover, all CIS subjects and 24 healthy controls underwent a brain MRI scan. Diffusion weighted imaging was used to compute mean diffusivity (MD) values in periventricular and deep NAWM for all groups. Results: CSF-OCB were present in 24 CIS subjects (CSF-OCB+) out of 34 tested. Periventricular NAWM MD values were significantly higher in CIS subjects with than in those without CSF-OCB (0.78 ± 0.06 mm 3 /10 −3 vs. 0.72 ± 0.06 mm 3 /10 −3 ; p = 0.01), while there was no difference between groups in deep NAWM MD values. The periventricular gradient of damage, expressed in z score based on healthy controls data, was more marked in CSF-OCB+ than in CSF-OCB− (0.65 ± 0.05 vs. 0.17 ± 0.04 p < 0.001). There was no difference in periventricular lesion load between the two groups. Conclusions: In CIS, the presence of CSF-OCB is associated with the severity of periventricular NAWM damage gradient. Intrathecal inflammation could play a role in NAWM damage distribution.
| Original language | English |
|---|---|
| Pages (from-to) | 93-96 |
| Number of pages | 4 |
| Journal | Multiple Sclerosis and Related Disorders |
| Volume | 31 |
| DOIs | |
| Publication status | Published - Jun 1 2019 |
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Keywords
- DWI
- MRI
- Multiple sclerosis
- White matter
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
CSF oligoclonal bands and normal appearing white matter periventricular damage in patients with clinically isolated syndrome suggestive of MS. / Pardini, Matteo; Gualco, Lorenzo; Bommarito, Giulia; Roccatagliata, Luca; Schiavi, Simona; Solaro, Claudio; Mancardi, Gianluigi; Uccelli, Antonio; Capello, Elisabetta; Inglese, Matilde.
In: Multiple Sclerosis and Related Disorders, Vol. 31, 01.06.2019, p. 93-96.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CSF oligoclonal bands and normal appearing white matter periventricular damage in patients with clinically isolated syndrome suggestive of MS
AU - Pardini, Matteo
AU - Gualco, Lorenzo
AU - Bommarito, Giulia
AU - Roccatagliata, Luca
AU - Schiavi, Simona
AU - Solaro, Claudio
AU - Mancardi, Gianluigi
AU - Uccelli, Antonio
AU - Capello, Elisabetta
AU - Inglese, Matilde
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Background: A periventricular gradient of normal appearing white matter (NAWM) damage has been described in multiple sclerosis (MS), including subjects with clinically isolated syndrome (CIS). The pathological mechanisms underlying this gradient is not currently understood. Methods: 34 CIS subjects were enrolled and underwent cerebrospinal fluid oligo-clonal bands (CSF-OCB) evaluation. Moreover, all CIS subjects and 24 healthy controls underwent a brain MRI scan. Diffusion weighted imaging was used to compute mean diffusivity (MD) values in periventricular and deep NAWM for all groups. Results: CSF-OCB were present in 24 CIS subjects (CSF-OCB+) out of 34 tested. Periventricular NAWM MD values were significantly higher in CIS subjects with than in those without CSF-OCB (0.78 ± 0.06 mm 3 /10 −3 vs. 0.72 ± 0.06 mm 3 /10 −3 ; p = 0.01), while there was no difference between groups in deep NAWM MD values. The periventricular gradient of damage, expressed in z score based on healthy controls data, was more marked in CSF-OCB+ than in CSF-OCB− (0.65 ± 0.05 vs. 0.17 ± 0.04 p < 0.001). There was no difference in periventricular lesion load between the two groups. Conclusions: In CIS, the presence of CSF-OCB is associated with the severity of periventricular NAWM damage gradient. Intrathecal inflammation could play a role in NAWM damage distribution.
AB - Background: A periventricular gradient of normal appearing white matter (NAWM) damage has been described in multiple sclerosis (MS), including subjects with clinically isolated syndrome (CIS). The pathological mechanisms underlying this gradient is not currently understood. Methods: 34 CIS subjects were enrolled and underwent cerebrospinal fluid oligo-clonal bands (CSF-OCB) evaluation. Moreover, all CIS subjects and 24 healthy controls underwent a brain MRI scan. Diffusion weighted imaging was used to compute mean diffusivity (MD) values in periventricular and deep NAWM for all groups. Results: CSF-OCB were present in 24 CIS subjects (CSF-OCB+) out of 34 tested. Periventricular NAWM MD values were significantly higher in CIS subjects with than in those without CSF-OCB (0.78 ± 0.06 mm 3 /10 −3 vs. 0.72 ± 0.06 mm 3 /10 −3 ; p = 0.01), while there was no difference between groups in deep NAWM MD values. The periventricular gradient of damage, expressed in z score based on healthy controls data, was more marked in CSF-OCB+ than in CSF-OCB− (0.65 ± 0.05 vs. 0.17 ± 0.04 p < 0.001). There was no difference in periventricular lesion load between the two groups. Conclusions: In CIS, the presence of CSF-OCB is associated with the severity of periventricular NAWM damage gradient. Intrathecal inflammation could play a role in NAWM damage distribution.
KW - DWI
KW - MRI
KW - Multiple sclerosis
KW - White matter
UR - http://www.scopus.com/inward/record.url?scp=85064241020&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064241020&partnerID=8YFLogxK
U2 - 10.1016/j.msard.2019.03.027
DO - 10.1016/j.msard.2019.03.027
M3 - Article
VL - 31
SP - 93
EP - 96
JO - Multiple Sclerosis and Related Disorders
JF - Multiple Sclerosis and Related Disorders
SN - 2211-0348
ER -