CSF oligoclonal bands and normal appearing white matter periventricular damage in patients with clinically isolated syndrome suggestive of MS

Matteo Pardini, Lorenzo Gualco, Giulia Bommarito, Luca Roccatagliata, Simona Schiavi, Claudio Solaro, Gianluigi Mancardi, Antonio Uccelli, Elisabetta Capello, Matilde Inglese

Research output: Contribution to journalArticle

Abstract

Background: A periventricular gradient of normal appearing white matter (NAWM) damage has been described in multiple sclerosis (MS), including subjects with clinically isolated syndrome (CIS). The pathological mechanisms underlying this gradient is not currently understood. Methods: 34 CIS subjects were enrolled and underwent cerebrospinal fluid oligo-clonal bands (CSF-OCB) evaluation. Moreover, all CIS subjects and 24 healthy controls underwent a brain MRI scan. Diffusion weighted imaging was used to compute mean diffusivity (MD) values in periventricular and deep NAWM for all groups. Results: CSF-OCB were present in 24 CIS subjects (CSF-OCB+) out of 34 tested. Periventricular NAWM MD values were significantly higher in CIS subjects with than in those without CSF-OCB (0.78 ± 0.06 mm 3 /10 −3 vs. 0.72 ± 0.06 mm 3 /10 −3 ; p = 0.01), while there was no difference between groups in deep NAWM MD values. The periventricular gradient of damage, expressed in z score based on healthy controls data, was more marked in CSF-OCB+ than in CSF-OCB− (0.65 ± 0.05 vs. 0.17 ± 0.04 p < 0.001). There was no difference in periventricular lesion load between the two groups. Conclusions: In CIS, the presence of CSF-OCB is associated with the severity of periventricular NAWM damage gradient. Intrathecal inflammation could play a role in NAWM damage distribution.

Original languageEnglish
Pages (from-to)93-96
Number of pages4
JournalMultiple Sclerosis and Related Disorders
Volume31
DOIs
Publication statusPublished - Jun 1 2019

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Oligoclonal Bands
Multiple Sclerosis
Cerebrospinal Fluid
White Matter
Healthy Volunteers
Magnetic Resonance Imaging
Inflammation
Brain

Keywords

  • DWI
  • MRI
  • Multiple sclerosis
  • White matter

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

CSF oligoclonal bands and normal appearing white matter periventricular damage in patients with clinically isolated syndrome suggestive of MS. / Pardini, Matteo; Gualco, Lorenzo; Bommarito, Giulia; Roccatagliata, Luca; Schiavi, Simona; Solaro, Claudio; Mancardi, Gianluigi; Uccelli, Antonio; Capello, Elisabetta; Inglese, Matilde.

In: Multiple Sclerosis and Related Disorders, Vol. 31, 01.06.2019, p. 93-96.

Research output: Contribution to journalArticle

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AU - Gualco, Lorenzo

AU - Bommarito, Giulia

AU - Roccatagliata, Luca

AU - Schiavi, Simona

AU - Solaro, Claudio

AU - Mancardi, Gianluigi

AU - Uccelli, Antonio

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AU - Inglese, Matilde

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