CSF T-cell subsets in multiple sclerosis: Relationship to cerebrospinal fluid myelin basic protein and clinical activity

A. Salmaggi, L. La Mantia, C. Milanese, G. Bianchi, M. Eoli, A. Campi, A. Nespolo

Research output: Contribution to journalArticle

Abstract

Cerebrospinal fluid myelin basic protein and cerebrospinal fluid and peripheral blood T-cell subsets have been studied in patients with multiple sclerosis and other inflammatory and non-inflammatory nervous system diseases. These biological parameters have been correlated with clinical disease activity. No changes in peripheral blood T-cell subsets were seen in multiple sclerosis patients. Low cerebrospinal fluid T8+ cells occurred only in multiple sclerosis, while high cerebrospinal fluid T4+ cells were detected both in clinically active multiple sclerosis and in inflammatory nervous system diseases. A close relationship was found between cerebrospinal fluid T4/T8 ratio and myelin basic protein in relapsing multiple sclerosis patients.

Original languageEnglish
Pages (from-to)336-339
Number of pages4
JournalJournal of Neurology
Volume236
Issue number6
DOIs
Publication statusPublished - Sep 1989

Fingerprint

Cerebrospinal Fluid Proteins
Myelin Basic Protein
T-Lymphocyte Subsets
Multiple Sclerosis
Cerebrospinal Fluid
Nervous System Diseases
Blood Cells
CD8-Positive T-Lymphocytes
CD4-Positive T-Lymphocytes
CD4-CD8 Ratio

Keywords

  • Multiple sclerosis
  • Myelin basic protein
  • T-cell subsets

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

CSF T-cell subsets in multiple sclerosis : Relationship to cerebrospinal fluid myelin basic protein and clinical activity. / Salmaggi, A.; La Mantia, L.; Milanese, C.; Bianchi, G.; Eoli, M.; Campi, A.; Nespolo, A.

In: Journal of Neurology, Vol. 236, No. 6, 09.1989, p. 336-339.

Research output: Contribution to journalArticle

Salmaggi, A. ; La Mantia, L. ; Milanese, C. ; Bianchi, G. ; Eoli, M. ; Campi, A. ; Nespolo, A. / CSF T-cell subsets in multiple sclerosis : Relationship to cerebrospinal fluid myelin basic protein and clinical activity. In: Journal of Neurology. 1989 ; Vol. 236, No. 6. pp. 336-339.
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