Abstract
Cerebrospinal fluid myelin basic protein and cerebrospinal fluid and peripheral blood T-cell subsets have been studied in patients with multiple sclerosis and other inflammatory and non-inflammatory nervous system diseases. These biological parameters have been correlated with clinical disease activity. No changes in peripheral blood T-cell subsets were seen in multiple sclerosis patients. Low cerebrospinal fluid T8+ cells occurred only in multiple sclerosis, while high cerebrospinal fluid T4+ cells were detected both in clinically active multiple sclerosis and in inflammatory nervous system diseases. A close relationship was found between cerebrospinal fluid T4/T8 ratio and myelin basic protein in relapsing multiple sclerosis patients.
Original language | English |
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Pages (from-to) | 336-339 |
Number of pages | 4 |
Journal | Journal of Neurology |
Volume | 236 |
Issue number | 6 |
DOIs | |
Publication status | Published - Sep 1989 |
Keywords
- Multiple sclerosis
- Myelin basic protein
- T-cell subsets
ASJC Scopus subject areas
- Neurology
- Clinical Neurology