CSF T-cell subsets in multiple sclerosis: Relationship to cerebrospinal fluid myelin basic protein and clinical activity

A. Salmaggi; L. La Mantia; C. Milanese; G. Bianchi; M. Eoli; A. Campi; A. Nespolo

doi:10.1007/BF00314375

CSF T-cell subsets in multiple sclerosis: Relationship to cerebrospinal fluid myelin basic protein and clinical activity

A. Salmaggi, L. La Mantia, C. Milanese, G. Bianchi, M. Eoli, A. Campi, A. Nespolo

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article

Abstract

Cerebrospinal fluid myelin basic protein and cerebrospinal fluid and peripheral blood T-cell subsets have been studied in patients with multiple sclerosis and other inflammatory and non-inflammatory nervous system diseases. These biological parameters have been correlated with clinical disease activity. No changes in peripheral blood T-cell subsets were seen in multiple sclerosis patients. Low cerebrospinal fluid T8+ cells occurred only in multiple sclerosis, while high cerebrospinal fluid T4+ cells were detected both in clinically active multiple sclerosis and in inflammatory nervous system diseases. A close relationship was found between cerebrospinal fluid T4/T8 ratio and myelin basic protein in relapsing multiple sclerosis patients.

Original language	English
Pages (from-to)	336-339
Number of pages	4
Journal	Journal of Neurology
Volume	236
Issue number	6
DOIs	https://doi.org/10.1007/BF00314375
Publication status	Published - Sep 1989

Keywords

Multiple sclerosis
Myelin basic protein
T-cell subsets

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1007/BF00314375

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Salmaggi, A., La Mantia, L., Milanese, C., Bianchi, G., Eoli, M., Campi, A., & Nespolo, A. (1989). CSF T-cell subsets in multiple sclerosis: Relationship to cerebrospinal fluid myelin basic protein and clinical activity. Journal of Neurology, 236(6), 336-339. https://doi.org/10.1007/BF00314375

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