Abstract
Cerebrospinal fluid myelin basic protein and cerebrospinal fluid and peripheral blood T-cell subsets have been studied in patients with multiple sclerosis and other inflammatory and non-inflammatory nervous system diseases. These biological parameters have been correlated with clinical disease activity. No changes in peripheral blood T-cell subsets were seen in multiple sclerosis patients. Low cerebrospinal fluid T8+ cells occurred only in multiple sclerosis, while high cerebrospinal fluid T4+ cells were detected both in clinically active multiple sclerosis and in inflammatory nervous system diseases. A close relationship was found between cerebrospinal fluid T4/T8 ratio and myelin basic protein in relapsing multiple sclerosis patients.
| Original language | English |
|---|---|
| Pages (from-to) | 336-339 |
| Number of pages | 4 |
| Journal | Journal of Neurology |
| Volume | 236 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Sep 1989 |
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Keywords
- Multiple sclerosis
- Myelin basic protein
- T-cell subsets
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
CSF T-cell subsets in multiple sclerosis : Relationship to cerebrospinal fluid myelin basic protein and clinical activity. / Salmaggi, A.; La Mantia, L.; Milanese, C.; Bianchi, G.; Eoli, M.; Campi, A.; Nespolo, A.
In: Journal of Neurology, Vol. 236, No. 6, 09.1989, p. 336-339.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CSF T-cell subsets in multiple sclerosis
T2 - Relationship to cerebrospinal fluid myelin basic protein and clinical activity
AU - Salmaggi, A.
AU - La Mantia, L.
AU - Milanese, C.
AU - Bianchi, G.
AU - Eoli, M.
AU - Campi, A.
AU - Nespolo, A.
PY - 1989/9
Y1 - 1989/9
N2 - Cerebrospinal fluid myelin basic protein and cerebrospinal fluid and peripheral blood T-cell subsets have been studied in patients with multiple sclerosis and other inflammatory and non-inflammatory nervous system diseases. These biological parameters have been correlated with clinical disease activity. No changes in peripheral blood T-cell subsets were seen in multiple sclerosis patients. Low cerebrospinal fluid T8+ cells occurred only in multiple sclerosis, while high cerebrospinal fluid T4+ cells were detected both in clinically active multiple sclerosis and in inflammatory nervous system diseases. A close relationship was found between cerebrospinal fluid T4/T8 ratio and myelin basic protein in relapsing multiple sclerosis patients.
AB - Cerebrospinal fluid myelin basic protein and cerebrospinal fluid and peripheral blood T-cell subsets have been studied in patients with multiple sclerosis and other inflammatory and non-inflammatory nervous system diseases. These biological parameters have been correlated with clinical disease activity. No changes in peripheral blood T-cell subsets were seen in multiple sclerosis patients. Low cerebrospinal fluid T8+ cells occurred only in multiple sclerosis, while high cerebrospinal fluid T4+ cells were detected both in clinically active multiple sclerosis and in inflammatory nervous system diseases. A close relationship was found between cerebrospinal fluid T4/T8 ratio and myelin basic protein in relapsing multiple sclerosis patients.
KW - Multiple sclerosis
KW - Myelin basic protein
KW - T-cell subsets
UR - http://www.scopus.com/inward/record.url?scp=0024324323&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024324323&partnerID=8YFLogxK
U2 - 10.1007/BF00314375
DO - 10.1007/BF00314375
M3 - Article
C2 - 2477508
AN - SCOPUS:0024324323
VL - 236
SP - 336
EP - 339
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
IS - 6
ER -