CT Appearance of Hepatocellular Carcinoma after Locoregional Treatments: A Comprehensive Review

Daniel Marin, Salvatore Cappabianca, Nicola Serra, Assunta Sica, Francesco Lassandro, Roberto D'Angelo, Michelearcangelo La Porta, Francesco Fiore, Francesco Somma

Research output: Contribution to journalArticlepeer-review


Hepatocellular carcinoma (HCC) is a major health problem worldwide, affecting more than 600,000 new patients per year. Curative treatments are available in a small percentage of patients, while most of them present in stages requiring locoregional treatments such as thermoablation, transarterial chemoembolization, and/or radioembolization. These therapies result in specific imaging features that the general radiologist has to be aware of in order to assess the response to treatment and to correctly manage the follow-up of treated patients. Multiphasic helical computed tomography has become a popular imaging modality for detecting hypervascular tumors and characterizing liver lesions. On this basis, many staging and diagnostic systems have been proposed for evaluating response to all different existing strategies. Radiofrequencies and microwaves generate thermoablation of tumors, and transarterial chemoembolization exploits the double effect of the locoregional administration of drugs and embolizing particles. Eventually radioembolization uses a beta-emitting isotope to induce necrosis. Therefore, the aim of this comprehensive review is to analyze and compare CT imaging appearance of HCC after various locoregional treatments, with regard to specific indications for all possible procedures.

Original languageEnglish
Article number670965
JournalGastroenterology Research and Practice
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Fingerprint Dive into the research topics of 'CT Appearance of Hepatocellular Carcinoma after Locoregional Treatments: A Comprehensive Review'. Together they form a unique fingerprint.

Cite this