CT image fusion as a tool for measuring in 3D the setup errors during conformal radiotherapy for prostate cancer

Research output: Contribution to journalArticle


Aims and background: The importance of optimal daily patient positioning has been stressed in order to ensure treatment reproducibitity and gain in accuracy and precision. We report our data on the 3D setup uncertainty during radiation therapy for prostate cancer using the CT image fusion technique. Methods: Ten consecutive patients scheduled for radiation therapy for prostate cancer underwent 5 prone position CT scans using an individualized immobilization cast. These different setups were analyzed using the image fusion module of the ERGO 30-Line Medical System (Milan, Italy) treatment planning system. The isocenter and the body marker displacements were measured. Results: The 3D isocenter dislocations were quantified: systematic error was Σ3D = 3.9 mm, whereas random error was σ3D = 1 mm. The mean of the minimum displacements was 0.2 ± 1 mm showing that the immobilization device used allows an accurate setup to be obtained. Single direction errors were also measured showing systematic errors, ΣAP = 2.6 mm, ΣLL = 0.6 mm, ΣSI = 3 mm in the anterior-posterior, latero-lateral, superior-inferior direction, respectively. Related random errors were σAP = 1 mm, σLL = 0.6 mm, σSI = 1.2 mm. In terms of accuracy, our uncertainties are similar to those reported in the literature. Conclusions: By applying the CT image fusion technique, a 3D study on setup accuracy was performed. We demonstrated that the use of an individualized immobilization system for prostate treatment is adequate to obtain good setup accuracy, as long as a high-quality positioning control method, such as the stereoscopic X-ray-based positioning system, is used.

Original languageEnglish
Pages (from-to)118-123
Number of pages6
Issue number2
Publication statusPublished - Mar 2006


  • Dynamic micro-multileaf collimator
  • Image fusion
  • Prostate cancer
  • Setup uncertainty

ASJC Scopus subject areas

  • Cancer Research

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