CT Radiogenomic Characterization of EGFR, K-RAS, and ALK Mutations in Non-Small Cell Lung Cancer

Research output: Contribution to journalArticle

Abstract

Objectives: To assess the association between CT features and EGFR, ALK, KRAS mutations in non-small cell lung cancer. Methods: Patients undergoing chest CT and testing for the above gene mutations were included. Qualitative evaluation of CTs included: lobe; lesion diameter; shape; margins; ground-glass opacity; density; cavitation; air bronchogram; pleural thickening; intratumoral necrosis; nodules in tumour lobe; nodules in non-tumour lobes; pleural retraction; location; calcifications; emphysema; fibrosis; pleural contact; pleural effusion. Statistical analysis was performed to assess association of features with each gene mutation. ROC curves for gene mutations were drawn; the corresponding area under the curve was calculated. P-values

Original languageEnglish
Pages (from-to)32-42
Number of pages11
JournalEuropean Radiology
Volume26
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Keywords

  • Anaplastic lymphoma kinase (ALK)
  • Computed Tomography (CT)
  • Epidermal growth factor receptor (EFGR)
  • Kirsten rat sarcoma (KRAS)
  • Non-small cell lung carcinoma (NSCLC)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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