CT Radiogenomic Characterization of EGFR, K-RAS, and ALK Mutations in Non-Small Cell Lung Cancer

Stefania Rizzo; Francesco Petrella; Valentina Buscarino; Federica De Maria; Sara Raimondi; Massimo Barberis; Caterina Fumagalli; Gianluca Spitaleri; Cristiano Rampinelli; Filippo De Marinis; Lorenzo Spaggiari; Massimo Bellomi

doi:10.1007/s00330-015-3814-0

CT Radiogenomic Characterization of EGFR, K-RAS, and ALK Mutations in Non-Small Cell Lung Cancer

Stefania Rizzo, Francesco Petrella, Valentina Buscarino, Federica De Maria, Sara Raimondi, Massimo Barberis, Caterina Fumagalli, Gianluca Spitaleri, Cristiano Rampinelli, Filippo De Marinis, Lorenzo Spaggiari, Massimo Bellomi

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article

Abstract

Objectives: To assess the association between CT features and EGFR, ALK, KRAS mutations in non-small cell lung cancer. Methods: Patients undergoing chest CT and testing for the above gene mutations were included. Qualitative evaluation of CTs included: lobe; lesion diameter; shape; margins; ground-glass opacity; density; cavitation; air bronchogram; pleural thickening; intratumoral necrosis; nodules in tumour lobe; nodules in non-tumour lobes; pleural retraction; location; calcifications; emphysema; fibrosis; pleural contact; pleural effusion. Statistical analysis was performed to assess association of features with each gene mutation. ROC curves for gene mutations were drawn; the corresponding area under the curve was calculated. P-values

Original language	English
Pages (from-to)	32-42
Number of pages	11
Journal	European Radiology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1007/s00330-015-3814-0
Publication status	Published - Jan 1 2016

Keywords

Anaplastic lymphoma kinase (ALK)
Computed Tomography (CT)
Epidermal growth factor receptor (EFGR)
Kirsten rat sarcoma (KRAS)
Non-small cell lung carcinoma (NSCLC)

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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Rizzo, S., Petrella, F., Buscarino, V., De Maria, F., Raimondi, S., Barberis, M., Fumagalli, C., Spitaleri, G., Rampinelli, C., De Marinis, F., Spaggiari, L., & Bellomi, M. (2016). CT Radiogenomic Characterization of EGFR, K-RAS, and ALK Mutations in Non-Small Cell Lung Cancer. European Radiology, 26(1), 32-42. https://doi.org/10.1007/s00330-015-3814-0

CT Radiogenomic Characterization of EGFR, K-RAS, and ALK Mutations in Non-Small Cell Lung Cancer. / Rizzo, Stefania ; Petrella, Francesco; Buscarino, Valentina; De Maria, Federica; Raimondi, Sara ; Barberis, Massimo ; Fumagalli, Caterina ; Spitaleri, Gianluca ; Rampinelli, Cristiano ; De Marinis, Filippo ; Spaggiari, Lorenzo ; Bellomi, Massimo.

In: European Radiology, Vol. 26, No. 1, 01.01.2016, p. 32-42.

Research output: Contribution to journal › Article

Rizzo, Stefania ; Petrella, Francesco ; Buscarino, Valentina ; De Maria, Federica ; Raimondi, Sara ; Barberis, Massimo ; Fumagalli, Caterina ; Spitaleri, Gianluca ; Rampinelli, Cristiano ; De Marinis, Filippo ; Spaggiari, Lorenzo ; Bellomi, Massimo. / CT Radiogenomic Characterization of EGFR, K-RAS, and ALK Mutations in Non-Small Cell Lung Cancer. In: European Radiology. 2016 ; Vol. 26, No. 1. pp. 32-42.

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