TY - JOUR
T1 - CT Radiogenomic Characterization of EGFR, K-RAS, and ALK Mutations in Non-Small Cell Lung Cancer
AU - Rizzo, Stefania
AU - Petrella, Francesco
AU - Buscarino, Valentina
AU - De Maria, Federica
AU - Raimondi, Sara
AU - Barberis, Massimo
AU - Fumagalli, Caterina
AU - Spitaleri, Gianluca
AU - Rampinelli, Cristiano
AU - De Marinis, Filippo
AU - Spaggiari, Lorenzo
AU - Bellomi, Massimo
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Objectives: To assess the association between CT features and EGFR, ALK, KRAS mutations in non-small cell lung cancer. Methods: Patients undergoing chest CT and testing for the above gene mutations were included. Qualitative evaluation of CTs included: lobe; lesion diameter; shape; margins; ground-glass opacity; density; cavitation; air bronchogram; pleural thickening; intratumoral necrosis; nodules in tumour lobe; nodules in non-tumour lobes; pleural retraction; location; calcifications; emphysema; fibrosis; pleural contact; pleural effusion. Statistical analysis was performed to assess association of features with each gene mutation. ROC curves for gene mutations were drawn; the corresponding area under the curve was calculated. P-values
AB - Objectives: To assess the association between CT features and EGFR, ALK, KRAS mutations in non-small cell lung cancer. Methods: Patients undergoing chest CT and testing for the above gene mutations were included. Qualitative evaluation of CTs included: lobe; lesion diameter; shape; margins; ground-glass opacity; density; cavitation; air bronchogram; pleural thickening; intratumoral necrosis; nodules in tumour lobe; nodules in non-tumour lobes; pleural retraction; location; calcifications; emphysema; fibrosis; pleural contact; pleural effusion. Statistical analysis was performed to assess association of features with each gene mutation. ROC curves for gene mutations were drawn; the corresponding area under the curve was calculated. P-values
KW - Anaplastic lymphoma kinase (ALK)
KW - Computed Tomography (CT)
KW - Epidermal growth factor receptor (EFGR)
KW - Kirsten rat sarcoma (KRAS)
KW - Non-small cell lung carcinoma (NSCLC)
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U2 - 10.1007/s00330-015-3814-0
DO - 10.1007/s00330-015-3814-0
M3 - Article
C2 - 25956936
AN - SCOPUS:84948718250
VL - 26
SP - 32
EP - 42
JO - European Radiology
JF - European Radiology
SN - 0938-7994
IS - 1
ER -