Ctla4 and multiple sclerosis in the Italian population

G. Malferrari, A. Stella, E. Monferini, G. Saltini, M. C. Proverbio, L. M. Grimaldi, L. Rossi-Bernardi, I. Biunno

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

CTLA4 protein is a receptor molecule that plays a critical role as a negative regulator of the immune response. Therefore, genetic variations in CTLA4 may confer susceptibility to autoimmune diseases such as multiple sclerosis (MS). In order to investigate the association of two CTLA4 polymorphisms (+49 A/G and -318 C/T) with multiple sclerosis, sporadic MS patients and healthy controls from Italy were genotyped through direct DNA sequencing. Considering single-loci variations, no differences in the allelic and genotypic frequencies between patients and controls were found. However, considering a putative interaction at the two loci, the T/G combination was more frequently observed in patients than in controls. This result suggests that this allelic combination of the CTLA4 polymorphisms may be involved in the susceptibility to MS in the Italian population.

Original languageEnglish
Pages (from-to)55-57
Number of pages3
JournalExperimental and Molecular Pathology
Volume78
Issue number1
DOIs
Publication statusPublished - Feb 2005

Fingerprint

Multiple Sclerosis
Polymorphism
Population
DNA Sequence Analysis
Italy
Autoimmune Diseases
Molecules
DNA
Proteins

Keywords

  • Association
  • Autoimmune disease
  • CTLA4
  • Multiple sclerosis
  • Polymorphism

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine

Cite this

Malferrari, G., Stella, A., Monferini, E., Saltini, G., Proverbio, M. C., Grimaldi, L. M., ... Biunno, I. (2005). Ctla4 and multiple sclerosis in the Italian population. Experimental and Molecular Pathology, 78(1), 55-57. https://doi.org/10.1016/j.yexmp.2004.10.001

Ctla4 and multiple sclerosis in the Italian population. / Malferrari, G.; Stella, A.; Monferini, E.; Saltini, G.; Proverbio, M. C.; Grimaldi, L. M.; Rossi-Bernardi, L.; Biunno, I.

In: Experimental and Molecular Pathology, Vol. 78, No. 1, 02.2005, p. 55-57.

Research output: Contribution to journalArticle

Malferrari, G, Stella, A, Monferini, E, Saltini, G, Proverbio, MC, Grimaldi, LM, Rossi-Bernardi, L & Biunno, I 2005, 'Ctla4 and multiple sclerosis in the Italian population', Experimental and Molecular Pathology, vol. 78, no. 1, pp. 55-57. https://doi.org/10.1016/j.yexmp.2004.10.001
Malferrari G, Stella A, Monferini E, Saltini G, Proverbio MC, Grimaldi LM et al. Ctla4 and multiple sclerosis in the Italian population. Experimental and Molecular Pathology. 2005 Feb;78(1):55-57. https://doi.org/10.1016/j.yexmp.2004.10.001
Malferrari, G. ; Stella, A. ; Monferini, E. ; Saltini, G. ; Proverbio, M. C. ; Grimaldi, L. M. ; Rossi-Bernardi, L. ; Biunno, I. / Ctla4 and multiple sclerosis in the Italian population. In: Experimental and Molecular Pathology. 2005 ; Vol. 78, No. 1. pp. 55-57.
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