Cumulative risk and protection effect of serotonergic genes on male antisocial behaviour: results from a prospective cohort assessed in adolescence and early adulthood

Stephanie Langevin, Sara Mascheretti, Sylvana Cote, Frank Vitaro, Michel Boivin, Gustavo Turecki, Richard T. Tremblay, Isabelle Ouellett-Morin

Research output: Contribution to journalArticle

Abstract

Background
Heritability of antisocial behaviour is estimated at approximately
50% and involves multiple genes.
Aims
To investigate the cumulative genetic effects of 116 single
nucleotide polymorphisms mapping to 11 candidate serotonergic
genes and antisocial behaviours, in adolescence and in early
adulthood.
Method
Participants were 410 male members of the Quebec Longitudinal
Study of Kindergarten Children, a population-based cohort followed
up prospectively from age 6 to age 23. The serotonergic
genes were selected based on known physiological processes
and prior associations with antisocial behaviours. Antisocial
behaviours were self-reported and assessed by using semistructured
interviews in adolescence and in adulthood.
Results
Cumulative, haplotype-based contributions of serotonergic
genes conferring risk and protection for antisocial behaviours
were detected by using multilocus genetic profile risk scores
(MGPRSs) and multilocus genetic profile protection scores
(MGPPSs). Cumulatively, haplotype-based MGPRSs and MGPPSs
contributed to 9.6, 8.5 and 15.2% of the variance in general
delinquency in adolescence, property/violent crimes in early
adulthood and physical partner violence in early adulthood,
respectively.
Conclusions
This study extends previous research by showing a cumulative
effect of multiple haplotypes conferring risk and protection to
antisocial behaviours in adolescence and early adulthood. The
findings further support the relevance of concomitantly considering
multiple serotonergic polymorphisms to better understand
the genetic aetiology of antisocial behaviours. Future studies
should investigate the interplay between risk and protective
haplotype-based multilocus genetic profile scores with the
environment.
Declaration of interest:
I.O.-M. holds a Canada Research Chair in the developmental
origins of vulnerability and resilience.
Keywords
Serotonin; haplotypes; genetics; multilocus genetic profile risk
scores; multilocus genetic profile protection scores.
Original languageEnglish
Number of pages9
JournalBritish Journal of Psychiatry
Publication statusE-pub ahead of print - 2018

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Haplotypes
Genes
Quebec
Crime
Research
Canada
Population

Keywords

  • Serotonin
  • haplotypes
  • genetics;
  • multilocus genetic profile risk scores
  • multilocus genetic profile protection scores

Cite this

Cumulative risk and protection effect of serotonergic genes on male antisocial behaviour: results from a prospective cohort assessed in adolescence and early adulthood. / Langevin, Stephanie; Mascheretti, Sara; Cote, Sylvana; Vitaro, Frank; Boivin, Michel; Turecki, Gustavo; Tremblay, Richard T.; Ouellett-Morin, Isabelle.

In: British Journal of Psychiatry, 2018.

Research output: Contribution to journalArticle

Langevin, Stephanie ; Mascheretti, Sara ; Cote, Sylvana ; Vitaro, Frank ; Boivin, Michel ; Turecki, Gustavo ; Tremblay, Richard T. ; Ouellett-Morin, Isabelle. / Cumulative risk and protection effect of serotonergic genes on male antisocial behaviour: results from a prospective cohort assessed in adolescence and early adulthood. In: British Journal of Psychiatry. 2018.
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T1 - Cumulative risk and protection effect of serotonergic genes on male antisocial behaviour: results from a prospective cohort assessed in adolescence and early adulthood

AU - Langevin, Stephanie

AU - Mascheretti, Sara

AU - Cote, Sylvana

AU - Vitaro, Frank

AU - Boivin, Michel

AU - Turecki, Gustavo

AU - Tremblay, Richard T.

AU - Ouellett-Morin, Isabelle

PY - 2018

Y1 - 2018

N2 - BackgroundHeritability of antisocial behaviour is estimated at approximately50% and involves multiple genes.AimsTo investigate the cumulative genetic effects of 116 singlenucleotide polymorphisms mapping to 11 candidate serotonergicgenes and antisocial behaviours, in adolescence and in earlyadulthood.MethodParticipants were 410 male members of the Quebec LongitudinalStudy of Kindergarten Children, a population-based cohort followedup prospectively from age 6 to age 23. The serotonergicgenes were selected based on known physiological processesand prior associations with antisocial behaviours. Antisocialbehaviours were self-reported and assessed by using semistructuredinterviews in adolescence and in adulthood.ResultsCumulative, haplotype-based contributions of serotonergicgenes conferring risk and protection for antisocial behaviourswere detected by using multilocus genetic profile risk scores(MGPRSs) and multilocus genetic profile protection scores(MGPPSs). Cumulatively, haplotype-based MGPRSs and MGPPSscontributed to 9.6, 8.5 and 15.2% of the variance in generaldelinquency in adolescence, property/violent crimes in earlyadulthood and physical partner violence in early adulthood,respectively.ConclusionsThis study extends previous research by showing a cumulativeeffect of multiple haplotypes conferring risk and protection toantisocial behaviours in adolescence and early adulthood. Thefindings further support the relevance of concomitantly consideringmultiple serotonergic polymorphisms to better understandthe genetic aetiology of antisocial behaviours. Future studiesshould investigate the interplay between risk and protectivehaplotype-based multilocus genetic profile scores with theenvironment.Declaration of interest:I.O.-M. holds a Canada Research Chair in the developmentalorigins of vulnerability and resilience.KeywordsSerotonin; haplotypes; genetics; multilocus genetic profile riskscores; multilocus genetic profile protection scores.

AB - BackgroundHeritability of antisocial behaviour is estimated at approximately50% and involves multiple genes.AimsTo investigate the cumulative genetic effects of 116 singlenucleotide polymorphisms mapping to 11 candidate serotonergicgenes and antisocial behaviours, in adolescence and in earlyadulthood.MethodParticipants were 410 male members of the Quebec LongitudinalStudy of Kindergarten Children, a population-based cohort followedup prospectively from age 6 to age 23. The serotonergicgenes were selected based on known physiological processesand prior associations with antisocial behaviours. Antisocialbehaviours were self-reported and assessed by using semistructuredinterviews in adolescence and in adulthood.ResultsCumulative, haplotype-based contributions of serotonergicgenes conferring risk and protection for antisocial behaviourswere detected by using multilocus genetic profile risk scores(MGPRSs) and multilocus genetic profile protection scores(MGPPSs). Cumulatively, haplotype-based MGPRSs and MGPPSscontributed to 9.6, 8.5 and 15.2% of the variance in generaldelinquency in adolescence, property/violent crimes in earlyadulthood and physical partner violence in early adulthood,respectively.ConclusionsThis study extends previous research by showing a cumulativeeffect of multiple haplotypes conferring risk and protection toantisocial behaviours in adolescence and early adulthood. Thefindings further support the relevance of concomitantly consideringmultiple serotonergic polymorphisms to better understandthe genetic aetiology of antisocial behaviours. Future studiesshould investigate the interplay between risk and protectivehaplotype-based multilocus genetic profile scores with theenvironment.Declaration of interest:I.O.-M. holds a Canada Research Chair in the developmentalorigins of vulnerability and resilience.KeywordsSerotonin; haplotypes; genetics; multilocus genetic profile riskscores; multilocus genetic profile protection scores.

KW - Serotonin

KW - haplotypes

KW - genetics;

KW - multilocus genetic profile risk scores

KW - multilocus genetic profile protection scores

M3 - Article

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

SN - 0007-1250

ER -