Cumulative risk and protection effect of serotonergic genes on male antisocial behaviour: Results from a prospective cohort assessed in adolescence and early adulthood

Stephanie Langevin, Sara Mascheretti, Sylvana M. Côté, Frank Vitaro, Michel Boivin, Gustavo Turecki, Richard E. Tremblay, Isabelle Ouellet-Morin

Research output: Contribution to journalArticle

Abstract

Background Heritability of antisocial behaviour is estimated at approximately 50% and involves multiple genes.Aims To investigate the cumulative genetic effects of 116 single nucleotide polymorphisms mapping to 11 candidate serotonergic genes and antisocial behaviours, in adolescence and in early adulthood.Method Participants were 410 male members of the Quebec Longitudinal Study of Kindergarten Children, a population-based cohort followed up prospectively from age 6 to age 23. The serotonergic genes were selected based on known physiological processes and prior associations with antisocial behaviours. Antisocial behaviours were self-reported and assessed by using semi-structured interviews in adolescence and in adulthood.Results Cumulative, haplotype-based contributions of serotonergic genes conferring risk and protection for antisocial behaviours were detected by using multilocus genetic profile risk scores (MGPRSs) and multilocus genetic profile protection scores (MGPPSs). Cumulatively, haplotype-based MGPRSs and MGPPSs contributed to 9.6, 8.5 and 15.2% of the variance in general delinquency in adolescence, property/violent crimes in early adulthood and physical partner violence in early adulthood, respectively.Conclusions This study extends previous research by showing a cumulative effect of multiple haplotypes conferring risk and protection to antisocial behaviours in adolescence and early adulthood. The findings further support the relevance of concomitantly considering multiple serotonergic polymorphisms to better understand the genetic aetiology of antisocial behaviours. Future studies should investigate the interplay between risk and protective haplotype-based multilocus genetic profile scores with the environment.Declaration of interest: I.O.-M. holds a Canada Research Chair in the developmental origins of vulnerability and resilience.

Original languageEnglish
Pages (from-to)137-145
Number of pages9
JournalBritish Journal of Psychiatry
Volume214
Issue number3
DOIs
Publication statusPublished - Mar 1 2019

Fingerprint

Haplotypes
Genes
Nucleotide Mapping
Physiological Phenomena
Quebec
Crime
Research
Canada
Single Nucleotide Polymorphism
Longitudinal Studies
Interviews
Population

Keywords

  • genetics
  • haplotypes
  • multilocus genetic profile protection scores
  • multilocus genetic profile risk scores
  • Serotonin

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Cumulative risk and protection effect of serotonergic genes on male antisocial behaviour : Results from a prospective cohort assessed in adolescence and early adulthood. / Langevin, Stephanie; Mascheretti, Sara; Côté, Sylvana M.; Vitaro, Frank; Boivin, Michel; Turecki, Gustavo; Tremblay, Richard E.; Ouellet-Morin, Isabelle.

In: British Journal of Psychiatry, Vol. 214, No. 3, 01.03.2019, p. 137-145.

Research output: Contribution to journalArticle

Langevin, Stephanie ; Mascheretti, Sara ; Côté, Sylvana M. ; Vitaro, Frank ; Boivin, Michel ; Turecki, Gustavo ; Tremblay, Richard E. ; Ouellet-Morin, Isabelle. / Cumulative risk and protection effect of serotonergic genes on male antisocial behaviour : Results from a prospective cohort assessed in adolescence and early adulthood. In: British Journal of Psychiatry. 2019 ; Vol. 214, No. 3. pp. 137-145.
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