Abstract
Curcumin belongs to the family of natural compounds collectively called curcuminoids and it possesses remarkable beneficial anti-oxidant, anti-inflammatory, anti-cancer, and neuroprotective properties. Moreover it is commonly assumed that curcumin has also been suggested as a remedy for digestive diseases such as inflammatory bowel diseases (IBD), a chronic immune disorder affecting the gastrointestinal tract and that can be divided in two major subgroups: Crohn's disease (CD) and Ulcerative Colitis (UC), depending mainly on the intestine tract affected by the inflammatory events. The chronic and intermittent nature of IBD imposes, where applicable, long-term treatments conducted in most of the cases combining different types of drugs. In more severe cases and where there has been no good response to the drugs, a surgery therapy is carried out. Currently, IBD-pharmacological treatments are generally not curative and often present serious side effects; for this reason, being known the relationship between nutrition and IBD, it is worthy of interesting the study and the development of new dietary strategy. The curcumin principal mechanism is the suppression of IBD inflammatory compounds (NF-B) modulating immune response. This review summarizes literature data of curcumin as anti-inflammatory and anti-oxidant in IBD, trying to understand the different effects in CD e UC.
| Original language | English |
|---|---|
| Pages (from-to) | 21127-21153 |
| Number of pages | 27 |
| Journal | Molecules |
| Volume | 19 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 1 2014 |
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Keywords
- Curcumin
- Inflammation
- Inflammatory bowel disease (ibd)
- Innovative treatments
ASJC Scopus subject areas
- Organic Chemistry
- Medicine(all)
Cite this
Curcumin and inflammatory bowel disease : Potential andlimits of innovative treatments. / Brumatti, Liza Vecchi; Marcuzzi, Annalisa; Tricarico, Paola Maura; Zanin, Valentina; Girardelli, Martina; Bianco, Anna Monica.
In: Molecules, Vol. 19, No. 12, 01.12.2014, p. 21127-21153.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Curcumin and inflammatory bowel disease
T2 - Potential andlimits of innovative treatments
AU - Brumatti, Liza Vecchi
AU - Marcuzzi, Annalisa
AU - Tricarico, Paola Maura
AU - Zanin, Valentina
AU - Girardelli, Martina
AU - Bianco, Anna Monica
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Curcumin belongs to the family of natural compounds collectively called curcuminoids and it possesses remarkable beneficial anti-oxidant, anti-inflammatory, anti-cancer, and neuroprotective properties. Moreover it is commonly assumed that curcumin has also been suggested as a remedy for digestive diseases such as inflammatory bowel diseases (IBD), a chronic immune disorder affecting the gastrointestinal tract and that can be divided in two major subgroups: Crohn's disease (CD) and Ulcerative Colitis (UC), depending mainly on the intestine tract affected by the inflammatory events. The chronic and intermittent nature of IBD imposes, where applicable, long-term treatments conducted in most of the cases combining different types of drugs. In more severe cases and where there has been no good response to the drugs, a surgery therapy is carried out. Currently, IBD-pharmacological treatments are generally not curative and often present serious side effects; for this reason, being known the relationship between nutrition and IBD, it is worthy of interesting the study and the development of new dietary strategy. The curcumin principal mechanism is the suppression of IBD inflammatory compounds (NF-B) modulating immune response. This review summarizes literature data of curcumin as anti-inflammatory and anti-oxidant in IBD, trying to understand the different effects in CD e UC.
AB - Curcumin belongs to the family of natural compounds collectively called curcuminoids and it possesses remarkable beneficial anti-oxidant, anti-inflammatory, anti-cancer, and neuroprotective properties. Moreover it is commonly assumed that curcumin has also been suggested as a remedy for digestive diseases such as inflammatory bowel diseases (IBD), a chronic immune disorder affecting the gastrointestinal tract and that can be divided in two major subgroups: Crohn's disease (CD) and Ulcerative Colitis (UC), depending mainly on the intestine tract affected by the inflammatory events. The chronic and intermittent nature of IBD imposes, where applicable, long-term treatments conducted in most of the cases combining different types of drugs. In more severe cases and where there has been no good response to the drugs, a surgery therapy is carried out. Currently, IBD-pharmacological treatments are generally not curative and often present serious side effects; for this reason, being known the relationship between nutrition and IBD, it is worthy of interesting the study and the development of new dietary strategy. The curcumin principal mechanism is the suppression of IBD inflammatory compounds (NF-B) modulating immune response. This review summarizes literature data of curcumin as anti-inflammatory and anti-oxidant in IBD, trying to understand the different effects in CD e UC.
KW - Curcumin
KW - Inflammation
KW - Inflammatory bowel disease (ibd)
KW - Innovative treatments
UR - http://www.scopus.com/inward/record.url?scp=84919754177&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84919754177&partnerID=8YFLogxK
U2 - 10.3390/molecules191221127
DO - 10.3390/molecules191221127
M3 - Article
C2 - 25521115
AN - SCOPUS:84919754177
VL - 19
SP - 21127
EP - 21153
JO - Molecules
JF - Molecules
SN - 1420-3049
IS - 12
ER -